PD-1-PD-L1-IN-44-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPD-1/PD-L1-IN-44Cat.No.:HY-161518分⼦式:C₃₄H₃₀N₂O₆分⼦量:562.61作⽤靶点:PD-1/PD-L1作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性PD-1/PD-L1-IN-44(Compound22)选择性的抑制PD-1/PD-L1蛋⽩(IC50=1.21nM)。PD-1/PD-L1-IN-44在动物模型中抑制了肿瘤⽣长，增强CD8+细胞浸润，且没有毒性[1]。体外研究PD-1/PD-L1-IN-44showsnon-specifictoxicity(IC50=>20μM(MDA-MB231),>20μM(H1299),>20μM(HCT116),>20μM(A549))[1].PD-1/PD-L1-IN-44(10μM;48h)effectivelyinhibitstheproliferationabilityofA549cellsinA549/PBMCTcells,andtheinhibitionrateevenreaches76.5%[1].Immunofluorescence[1]CellLine:A549/PBMCTcellsConcentration:10μMIncubationTime:48hResult:InhibitedcellproliferationmorethanBMS-1(HY-19991)andBMS-1166(HY-102011).InducedPBMCTcellstokillA549cells体内研究PD-1/PD-L1-IN-44(10mg/kg;i.p.;oncedailyfor21days)significantlyinhibitstumorgrowthin4T1modelmice[1].Dissolvedformulationofthedrugwas5%DMSO,10%Castoroil,85%salineREFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].ZhangY,etal.ImprovingtumorsensitivitybytheintroductionofanesterchaintotriarylderivativestargetingPD-1/PD-L1.EurJMedChem.2024May5;271:116433.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: