Pamiparib-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPamiparib(Standard)Cat.No.:HY-104044RCASNo.:1446261-44-4分⼦式:C₁₆H₁₅FN₄O分⼦量:298.31作⽤靶点:PARP作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Pamiparib(Standard)Pamiparib的分析标准品。本产品⽤于研究及分析应⽤。Pamiparib(BGB-290)⼀种有效的，具有⼝服活性的⾼选择性PARP抑制剂，对PARP1和PARP2的IC50值分别为0.9nM和0.5nM。Pamiparib能透过⾎脑屏障，可⽤于包括实体瘤在内的多种肿瘤的研究[1][2]。IC50&TargetPARP[1]REFERENCES[1].ChangyouZhou,etal.Fusedtetraorpenta-cyclicdihydrodiazepinocarbazolonesasparpinhibitors.WO2013097225A1.[2].FriedlanderM,etal.Pamiparibincombinationwithtislelizumabinpatientswithadvancedsolidtumours:resultsfromthedose-escalationstageofamulticentre,open-label,phase1a/btrial.LancetOncol.2019Sep;20(9):1306-1315.[3].ZhiyuTang,etal.Abstract1653:BGB-290:AhighlypotentandspecificPARP1/2inhibitorpotentiatesanti-tumoractivityofchemotherapeuticsinpatientbiopsyderivedSCLCmodels.CancerResearch.August2015,Volume75,Issue15.[4].ShivK.Gupta,etal.Abstract3505:InhibitionofPARPactivitybyBGB-290potentiatesefficacyofNSC362856inpatientderivedxenograftsofglioblastomamultiforme.CancerResearch.August2015,Volume75,Issue15McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: