MK-0493-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMK-0493hydrochlorideCat.No.:HY-118930ACASNo.:455957-71-8分⼦式:C₃₀H₃₉Cl₂F₂N₃O₂分⼦量:582.55作⽤靶点:MelanocortinReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:200mg/mL(343.32mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7166mL8.5830mL17.1659mL5mM0.3433mL1.7166mL3.4332mL10mM0.1717mL0.8583mL1.7166mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性MK-0493hydrochloride有效的、具有⼝服活性的、选择性的⿊⽪质激素受体4(MC4R)的激动剂，可明显减少⾷物摄⼊。REFERENCES[1].KrishnaR,etal.Potentandselectiveagonismofthemelanocortinreceptor4withMK-0493doesnotinduceweightlossinobesehuman1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEsubjects:energyintakepredictslackofweightlossefficacy.ClinPharmacolTher.2009Dec;86(6):659-66.[2].SezenSF,etal.Intracavernosalpressuremonitoringinmice:responsestoelectricalstimulationofthecavernousnerveandtointracavernosaldrugadministration.JAndrol.2000Mar-Apr;21(2):311-5.[3].HongQ,etal.Discoveryofapiperazineureabasedcompoundasapotent,selective,orallybioavailablemelanocortinsubtype-4receptorpartialagonist.BioorgMedChemLett.2011Apr15;21(8):2330-4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955