免疫细胞培养细胞因子

免疫细胞培养细胞因子支持多种免疫细胞培养低内毒素高纯度、高活性、高批间一致性GMP级、无动物源细胞因子可供选择高品质细胞因子T细胞培养更多免疫细胞培养相关产品GMP级CD3

(OKT3)/CD28激活抗体CAR-T/CAR-NK细胞检测流式抗体细胞因子检测ELISA试剂盒P

04

自然杀伤（NK）细胞培养目录树突状（DC）细胞培养P

08

B细胞培养单核/巨噬细胞培养P

10

粒细胞培养P

01P

02P

06P

09P

1

1免疫细胞培养细胞因子北京义翘神州科技股份有限公司免疫细胞培养细胞因子01高品质细胞因子近年来，过继性免疫细胞治疗已成为肿瘤免疫疗法的研究热点，包括CAR-M、CAR-NK、CAR-T、TCR-T、NK、DC、CIK等。细胞因子能够调节免疫细胞的增殖与分化、信号转导等，是免疫细胞培养、细胞与基因治疗药物（CGT）开发过程中所必需的试剂。义翘神州致力于免疫细胞治疗相关研究，自主研发并建立了重组蛋白生产平台、抗体开发平台、严谨的质量控制检测平台以及GMP质量管理体系，开发了一系列高品质细胞因子，具有高活性、低内毒素、高批间一致性和高纯度等特点，以支持免疫细胞培养、免疫细胞疗法、药物研发和疫苗开发等研究，全面助力细胞治疗的开发进程。另有GMP级、无动物源细胞因子可供选择！支持多种免疫细胞培养高纯度、高活性和高批间一致性低内毒素无标签或小标签表达GMP级、无动物源细胞因子可供选择纯度经SDS/SEC-HPLC验证生物活性经细胞水平验证完善的质量控制体系产品特点资质证书2024年值得关注的生长因子供应商CNAS证书FDA

DMF备案ISO

9001:2015证书ISO

13485:2016证书GMP证书北京义翘神州科技股份有限公司02免疫细胞培养细胞因子CAR-T和肿瘤浸润淋巴细胞疗法等T细胞介导的癌症疗法的进步为癌症治疗开辟了新的可能性。IL-2是一种常用于T细胞培养的有效细胞因子，以促进效应T细胞和记忆T细胞的增殖和分化。IL-4、IL-7、IL-15和IL-21在记忆T细胞的形成、增殖和存活中发挥重要的作用。产品数据展示GMP-grade

Human

IL-21

(Cat#:

GMP-10584-HNAE)高纯度

高活性

经HPLC验证低内毒素高批间一致性NaïveGata3IL-15NKTRorγtFoxp3Stat6Gata3TbetBcl6IL-6,

IL-21TFHIFNγTNF

αIL-10TGF

βIL-9IL-4IFNγ抗病毒IL-17IL-21TNF

α抵御胞外细菌免疫调节抗肿瘤防御过敏和哮喘抵御细胞内病原体IL6IL-21TGF

β抵御自身免疫TGF

β+IL-6Th17TGF

β+IL-2TregTGF

β+IL-4Th9IL-4Th2IL-12Th1Naïve

T细胞分化为不同T细胞亚群相关的细胞因子义翘神州致力于开发应用于CAR-T细胞疗法的高质量试剂产品，严格遵循质量管理体系和药品级放行检测标准，药品级生产环境及生产管理，成功开发了一系列如IL-2、IL-7、IL-15和IL-21等高质量的GMP级细胞因子，助力T细胞培养和细胞治疗药物研发。16001400120010008006004002000Conc

of

SecretionIFN-γ.(pg/ml)Competitor

R

Sinobiological1E-3

0.01

0.1

1

10

100Human

IL-21

Conc.

(ng/mL)Induced

Interferon

gamma

secretion

byhuman

natural

killer

lymphoma

NK-92

cellsThree

and

five

cycles

of

freeze-thaw

testswere

conducted

to

verify

GMP-gradehuman

IL-21

stability.1E-3

0.01

0.1

1

10

100Human

IL-21

Conc.

(ng/mL)16001400120010008006004002000-200Conc

of

SecretionIFN-γ.(pg/ml)冻融0次冻融3次冻融5次T细胞培养Two

independentlots

ofGMP-gradehuman

IL-21

showed

identical

bioactivity.1E-3

0.01

0.1

1

1010016001400120010008006004002000Conc

of

Secretion

IFN-r.

(pg/mL)Human

IL-21Conc.(ng/mL)Batch

1Batch

2北京义翘神州科技股份有限公司免疫细胞培养细胞因子03HPLC-VerifiedAnimal-FreeGMP-Grade

AvailableT细胞培养细胞因子推荐细胞因子货号种属表达宿主纯度内毒素B7-H2/ICOSLG11559-HNAHHumanHEK293

Cells≥

95%<

1.0

EU/µgBMP410609-HNAE2HumanE.

coli≥

95%<

1.0

EU/µgbasic

FGF/FGF210014-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10014-HNAEHumanE.

coli≥

95%<

10

EU/mgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1

beta10139-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10139-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-211848-HNAE2HumanE.

coli>

95%<

5

EU/mgGMP-11848-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-711821-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-11821-HNAEHumanE.

coli≥

95%<

10

EU/mgIL-12CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgGMP-CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgIL-1510360-HNCEHumanE.

coli≥

95%<20

EU/mgGMP-10360-HNCEHumanE.

coli≥

95%<

5

EU/mgIL-1810119-HNCEHumanE.

coli>

95%<

10

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIL-23CT048-H08HHumanHEK293

Cells>

90%<

1.0

EU/µgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgTGF

beta

110804-HNACHuman,

Rhesus,Cynomolgus,

CanineCHO

Stable

Cells>

95%<

1.0

EU/µg10804-H08HHumanHEK293

Cells>

95%<

1.0

EU/µgTGF-beta

3/TGFB310434-H01HHumanHEK293

Cells>

90%<

1.0

EU/µgTNF-alpha10602-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10602-HNAEHumanE.

coli≥

95%<

5

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/µg北京义翘神州科技股份有限公司04免疫细胞培养细胞因子自然杀伤细胞分化与培养相关的细胞因子自然杀伤（NK）细胞是具有高度细胞毒性的非特异性免疫效应细胞，可杀死被病原体感染的细胞和癌细胞，并释放细胞因子，招募其他免疫细胞共同发挥作用。CAR-NK细胞疗法在血液瘤和实体瘤的治疗中具有显著的效果。与CAR-T疗法相比，CAR-NK细胞疗法更安全。细胞因子对于NK细胞的发育和存活具有重要调节作用。如IL-21能诱导NK细胞的成熟，并增强其细胞毒性。义翘神州成功开发出高质量、高活性的细胞因子，如IL-2、IL-7、IL-12、IL-15和IL-21等助力NK细胞培养和CAR-NK细胞治疗药物研发。自然杀伤（NK）细胞培养HSCCLPNKPiNKmNKCytotoxicTolerantRegulatoryKL,

FL,

IL-3,

IL-7KL,

FL,

IL-15IL-15IL-15IL-2/IL-15IL-12/IL-18/IL-21TGF-β

IL-10TGFβ/IL-15应用案例展示NK细胞分化HumanIL-2,

IL-15,

and

IL-21

(Cat#:

11848-HNAH1-E;

Cat#:

10360-HNCE;

Cat#:

10584-HNAE)Medium

IL-2

IL-15

IL-21CD3-

CD56

dim

CD3-

CD56

bright3.52

0.63CD3-

CD56

dim

CD3-

CD56

bright5.43

1.16CD3-

CD56

dim

CD3-

CD56

bright6.59

1.24CD3-

CD56

dim

CD3-

CD56

bright6.02

0.87IL-2

+

IL-15IL-2

+

IL-21IL-15

+

IL-21UnstainedCD3-

CD56

dim

CD3-

CD56

bright5.45

0.94CD3-

CD56

dim

CD3-

CD56

bright6.65

1.56CD3-

CD56

dim

CD3-

CD56

bright7.61

1.11CD3-

CD56

dim

CD3-

CD56

bright0.068

0.011CD3CD56Natural

killer

(NK)

cells

expansion

was

detected

by

FACS

analysis.Representative

graphs

of

CD3−CD56+

(CD56bright

and

CD56dim)

expressing

cells

demonstrated

3-day

treatment

of

γccytokine

(20

ng/mL

IL-2,

20

ng/mL

IL-15,

and

25

ng/mL

IL-21)

induced

NK

cells

expansion.DOI:

10.1155/2023/8924603北京义翘神州科技股份有限公司免疫细胞培养细胞因子05细胞因子货号种属表达宿主纯度内毒素BMP410609-HNAE2HumanE.

coli≥

95%<

1.0

EU/µgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-211848-HNAE2HumanE.

coli>

95%<

5

EU/mgGMP-11848-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-711821-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-11821-HNAEHumanE.

coli≥

95%<

10

EU/mgIL-12CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgGMP-CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgIL-1510360-HNCEHumanE.

coli≥

95%<20

EU/mgGMP-10360-HNCEHumanE.

coli≥

95%<

5

EU/mgIL-1810119-HNCEHumanE.

coli>

95%<

10

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgVEGF16511066-HNAHHuman,

CynomolgusHEK293

Cells≥

95%<

10

EU/mg产品数据展示NK细胞培养细胞因子推荐经HPLC验证高活性高纯度GMP-grade

Human

IL-2(Cat#:

GMP-11848-HNAE)GMP-grade

Human

IL-15(Cat#:

GMP-10360-HNCE)低内毒素高批间一致性Cell

proliferation

assay

using

CTLL2.

The

specific

activity

ofrecombinant

human

IL-2

is

approximately

20,000

IU/µg0.1600

ED50=1-8

ng/mL5004003002001000-100Proliferation,

%1

10Human

IL-2

Conc.

(ng/mL)ED50=0.5-5

ng/mL0.01

0.1

1

10

100-5000Human

IL-15Conc.

(ng/mL)Measuredin

a

cell

proliferationassay

usingMO7e

humanmegakaryocytic

leukemic

cells.300002500020000150001000050000Proliferation,%HPLC-VerifiedAnimal-FreeGMP-Grade

Available06免疫细胞培养细胞因子树突状细胞分化与发育相关的细胞因子义翘神州开发了一系列高纯度、高生物活性、低内毒素的高品质细胞因子，全面支持DC细胞培养、DC疫苗开发和免疫细胞治疗等研究。树突状细胞（DC）是已知功能最强的功能性抗原提呈细胞，可激活CD4+辅助T细胞和CD8+细胞毒性T细胞。成熟的DC细胞抗原提呈能力和启动免疫应答能力增强，可分泌细胞因子刺激T淋巴细胞发挥免疫效应。利用GM-CSF和IL-4诱导可在体外得到未成熟的DC细胞，再加入TNF-α进行体外诱导培养，即可得到成熟的DC细胞。树突状（DC）细胞培养SCFM-CSFSCFFLT3LGM-CSF,

IL-4TNF-a,

IL-6,

IL-1β,

IFN-γGM-CSF,

IL-4FLT3LIL-3GM-CSF,

IL-4HSCMyeloid

precursorMonocyteCDPLymphoid

precursor

Plasmacytic

cellpre-cDCPlasmacytoid

DCMature

DCcDC1cDC2Immature

DCMature

monocyte-drived

DC外周血PBMC101

102

103

104

105

106

1074.0K3.0K2.0KCount1.0K0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0应用案例展示DC细胞分化GMP-grade

Human

GM-CSF,

IL-4,

and

TNF-alpha(Cat#:

GMP-10015-HNAH;

Cat#:

GMP-11846-HNAE;

Cat#:

GMP-10602-HNAE)Immature

DCsSSC-H500K1.0M1.5M0SSC-H500K1.0M1.5M0SSC-H500K1.0M1.5M0Count2.5K2.0K1.5K1.0K5000101

102

103

104

105

106

107

101

102

103

104

105

106

107

101

102

103

104

105

106

107

101

102

103

104

105

106

107

101

102

103

104

105

106

107Dendritic

Cells

(DCs)

generation

and

maturation

were

detected

by

FACS

analysis.CD14+

monocytes

were

differentiated

into

immature

DCs

by

GM-CSF

(Cat#:

GMP-10015-HNAH)

and

IL-4(Cat#:

GMP-11846-HNAE)

for

6

days.

DCs

were

matured

by

TNF

(Cat#:

GMP-10602-HNAE)

for

2

days.北京义翘神州科技股份有限公司Count1.0K1.5K2.0K5000Mature

DCs北京义翘神州科技股份有限公司免疫细胞培养细胞因子07产品数据展示经HPLC验证高活性高纯度GMP-grade

Human

IL-4(Cat#:

GMP-11846-HNAE)GMP-grade

Human

TNF-alpha(Cat#:

GMP-10602-HNAE)低内毒素高批间一致性Cell

proliferation

assay

using

TF-1

humanerythroleukemic

cellsCytotoxicity

assay

using

L929

mouse

fibrosarcoma

cellsin

the

presence

of

the

metabolic

inhibitor

actinomycin

D-1001E-5

1E-4

1E-3

0.01

0.1

1 10

100Human

IL-4

Conc.

(ng/mL)8007006005004003002001000Proliferation,%Sinobiological

CompetitorR1E-3

0.01

0.11 10

100

1000

10000-20100806040200Cytotoxicity,%Human

TNF-α

Conc.(ng/mL)Sinobiological

CompetitorRDC细胞培养细胞因子推荐HPLC-VerifiedAnimal-FreeGMP-Grade

Available细胞因子货号种属表达宿主纯度内毒素BMP410609-HNAE2HumanE.

coli≥

95%<

1.0

EU/µgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgGM-CSF/CSF210015-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGMP-10015-HNAHHumanHEK293

Cells≥

95%<

5

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1

beta10139-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10139-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1010947-HNAEHumanE.

coli≥

95%<20

EU/mgM-CSF/CSF111792-HNAH1HumanHEK293

Cells≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/µgTNF-alpha10602-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10602-HNAEHumanE.

coli≥

95%<

5

EU/mgVEGF16511066-HNAHHuman,

CynomolgusHEK293

Cells≥

95%<

10

EU/mg北京义翘神州科技股份有限公司08免疫细胞培养细胞因子B细胞可产生抗体介导体液免疫应答，在适应性免疫应答中发挥重要作用，主要包括中和作用、调理吞噬作用、参与补体的溶细胞或溶菌作用以及ADCC作用。B细胞作为抗原提呈细胞，能捕获可溶性抗原，但只有活化的B细胞才能提呈抗原。此外，B细胞可分泌细胞因子参与炎症反应和造血等过程。在B细胞的发育过程中，有多种细胞因子会影响B细胞的生长和存活。IL-4和IL-6可影响B细胞优先分泌特定类别的抗体，IL-7主要使发育中的B细胞存活。义翘神州开发了一系列高纯度、高生物活性、低内毒素的高品质细胞因子，全面支持B细胞培养及其相关研究。B细胞培养产品数据展示GMP-grade

Human

IL-7

(Cat#:

GMP-11821-HNAE)高纯度

高活性

经HPLC验证低内毒素高批间一致性5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE

andSEC-HPLCCell

proliferation

assay

using

anti-CD3antibody

activated

human

peripheralblood

mononuclear

cellCell

proliferation

assay

using

anti-CD3antibody

activated

human

peripheralblood

mononuclear

cell

(PBMC)kDa

M

11666.245.035.025.018.414.4mAU

7060504030201000.11

10

100Human

IL-7

Conc.

(ng/mL)10009008007006005004003002001000Proliferation,%Batch

1Batch

20.1

1

1010010009008007006005004003002001000Proliferation,%Human

IL-7

Conc.

(ng/mL)Competitor

R

SinobiologicalB细胞培养细胞因子推荐HPLC-VerifiedAnimal-FreeGMP-Grade

Available细胞因子货号种属表达宿主纯度内毒素BAFF/BLyS/TNFSF13B10056-HNCHHumanHEK293

Cells>

95%<

1.0

EU/µgCD40

Ligand/TNFSF510239-H01HHumanHEK293

Cells≥

95%<

1.0

EU/µgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-211848-HNAE2HumanE.

coli>

95%<

5

EU/mgGMP-11848-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-711821-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-11821-HNAEHumanE.

coli≥

95%<

10

EU/mgIL-1010947-HNAEHumanE.

coli≥

95%<20

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mg免疫细胞培养细胞因子09单核/巨噬细胞是机体重要的免疫细胞，具有抗感染、抗肿瘤、呈递抗原以及免疫调节等重要作用，可清除病原体、受损细胞并刺激适应性免疫应答，与慢性疾病、自身免疫性疾病、纤维化、糖尿病和肿瘤的发生和进展相关。GM-CSF、IFN

gamma、IL-4和M-CSF与单核/巨噬细胞体外培养密切相关，义翘神州已开发了一系列高品质细胞因子，全面支持单核/巨噬细胞培养、疾病治疗、新型肿瘤疗法开发等相关研究。产品数据展示GMP-grade

Human

IFN

gamma

(Cat#:

GMP-11725-HNAE)单核/巨噬细胞培养经HPLC验证高活性高纯度低内毒素高批间一致性单核/巨噬细胞培养细胞因子推荐0.11

10

100HumanIFN-gamma

Conc.

(ng/mL)0.300.250.350.400.450.50OD-BlankEC50=0.06-0.3

ng/mLmAU120100806040200kDa

M

11666.245.035.025.018.414.45

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE

andSEC-HPLCMeasuredin

anti-viral

assays

using

WISH

cells

infectedwith

vesicular

stomatitisvirus

(VSV)HPLC-Verified Animal-Free北京义翘神州科技股份有限公司GMP-Grade

Available细胞因子货号种属表达宿主纯度内毒素GM-CSF/CSF210015-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGMP-10015-HNAHHumanHEK293

Cells≥

95%<

5

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1010947-HNAEHumanE.

coli≥

95%<20

EU/mgIL-1310369-HNACHumanCHO

StableCells>

92%<

1.0

EU/µgM-CSF/CSF111792-HNAH1HumanHEK293

Cells≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/µgIL-1

beta10139-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10139-HNAEHumanE.

coli≥

95%<

5

EU/mgTGF

beta

110804-HNACHuman,

Rhesus,Cynomolgus,

CanineCHO

StableCells>

95%<

1.0

EU/µg10804-H08HHumanHEK293

Cells>

95%<

1.0

EU/µg北京义翘神州科技股份有限公司10免疫细胞培养细胞因子粒细胞是一类高异质性的白细胞，可分为中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞和肥大细胞。粒细胞被活化后，会释放免疫刺激分子来抵抗病毒和寄生虫感染，并分泌细胞因子将其他免疫细胞募集到炎症部位，共同发挥免疫调节作用；此外，粒细胞在慢性炎症、哮喘、过敏、自身免疫和癌症等多种疾病中都发挥着重要的作用。义翘神州已开发了一系列高纯度、高生物活性、低内毒素的高品质细胞因子，全面支持粒细胞等相关免疫研究，另有GMP级细胞因子可供选择，欢迎选购。粒细胞培养产品数据展示GMP-grade

Human

GM-CSF/CSF2

(Cat#:

GMP-10015-HNAH)经HPLC验证高活性高纯度低内毒素高批间一致性5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE

andSEC-HPLCMeasuredin

anti-viral

assays

using

WISH

cells

infectedwith

vesicular

stomatitisvirus

(VSV)粒细胞培养细胞因子推荐HPLC-VerifiedAnimal-FreeGMP-Grade

Available1E-5

1E-4

1E-3

0.01

0.1110

10010000200030004000Proliferation

%HumanGM-CSFConc.

(ng/mL)ED50=0.06-0.3

ng/mLmAU

100020406080kDa

M

11666.245.035.025.018.414.4细胞因子货号种属表达宿主纯度内毒素G-CSF10007-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGM-CSF/CSF210015-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGMP-10015-HNAHHumanHEK293

Cells≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-515673-HNCEHumanE.

coli>

95%IL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgM-CSF/CSF111792-HNAH1HumanHEK293

Cells≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/µgVEGF16511066-HNAHHuman,

CynomolgusHEK293

Cells≥

95%<

10

EU/mg北京义翘神州科技股份有限公司免疫细胞培养细胞因子11义翘神州致力于开发高质量的用于细胞治疗研究及临床的相关试剂，除RUO级和GMP级细胞因子之外，我们还提供CD3

(OKT3)/CD28激活抗体、CAR-T/CAR-NK细胞检测流式抗体和细胞因子检测ELISA试剂盒等高品质产品，更好地助力细胞治疗药物开发和生产。更多免疫细胞培养相关产品GMP级CD3

(OKT3)单克隆抗体(Cat#:

GMP-10977-H001)GMP级CD28单克隆抗体(Cat#:

GMP-11524-H001)Effect

of

human

CD3

(humanized

OKT3)

antibodyon

the

proliferation

and

IFN-gamma

secretion

ofCD4+

T

cellsGMP级CD3

(OKT3)/CD28激活抗体CAR-T/CAR-NK细胞检测流式抗体特异性好

亲和力佳

信噪比优多种标记严格按照GMP规范生产，质量标准参照《中国药典》2020版四部

15项质控指标，涵盖支原体、异常毒性、宿主DNA残留、HCP残留等高纯度，超低内毒素（<0.5

EU/mg），高生物活性高批间一致性，现货供应400200060080010000.1101Anti-CD3(µg/mL)Proliferation,%300250200150100503501E-4