Amifostine-trihydrate-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAmifostinetrihydrate(Standard)Cat.No.:HY-B0639ARCASNo.:112901-68-5分⼦式:C₅H₂₁N₂O₆PS分⼦量:268.27作⽤靶点:MDM-2/p53;HIF/HIFProlyl-Hydroxylase作⽤通路:Apoptosis;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Amifostine(trihydrate)(Standard)Amifostine(trihydrate)的分析标准品。本产品⽤于研究及分析应⽤。Amifostinetrihydrate(WR2721trihydrate)⼀种⼴谱细胞保护剂和辐射防护剂。Amifostinetrihydrate可选择性保护正常组织免受放射线和化学疗法造成的损害。Amifostinetrihydrate有效的HIF-α1和p53诱导剂。Amifostinetrihydrate通过除氧衍⽣的⾃由来保护细胞免受损伤。Amifostinetrihydrate可降低肾脏毒性并具有抗⾎管⽣成作⽤。REFERENCES[1].DMaurici,etal.Amifostine(WR2721)restorestranscriptionalactivityofspecificp53mutantproteinsinayeastfunctionalassay.Oncogene.2001Jun14;20(27):3533-40.[2].EfstathiaGiannopoulou,etal.Amifostineinhibitsangiogenesisinvivo.JPharmacolExpTher.2003Feb;304(2):729-37.[3].MichaelIKoukourakis,etal.Amifostineinducesanaerobicmetabolismandhypoxia-induciblefactor1alpha.CancerChemotherPharmacol.2004Jan;53(1):8-14.[4].JohnRKouvaris,etal.Amifostine:thefirstselective-targetandbroad-spectrumradioprotector.Oncologist.2007Jun;12(6):738-47.[5].Shao-ZeWu,etal.AmifostinePretreatmentAttenuatesMyocardialIschemia/ReperfusionInjurybyInhibitingApoptosisandOxidativeStress.OxidMedCellLongev.2017;2017:4130824.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>