2-Hydroxychalcone-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE2′-Hydroxychalcone-1Cat.No.:HY-W012349CASNo.:1214-47-7分⼦式:C₁₅H₁₂O₂分⼦量:224.25作⽤靶点:NF-κB;Fungal;Apoptosis;Autophagy作⽤通路:NF-κB;Anti-infection;Apoptosis;Autophagy储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY⽣物活性2'-Hydroxychalcone查尔酮的羟衍⽣物，具有抗癌活性。2'-Hydroxychalcone抑制NF-κB通路并诱导乳腺癌细胞⾃噬(autophagy)和凋亡(apoptosis)。2′-Hydroxychalcone对复合副球孢⼦属显⽰出更好的抗真活性。体外研究2′-Hydroxychalcone(10-90μM;12-72h)suppressescellviabilityinadose-dependentmanner,withIC50valuesof37.74μMand34.26μMforthetwobreastcancercelllinesMCF-7andCMT-1211,respectively[1].2′-Hydroxychalcone(10-30μM;24h)promotesautophagyvesicleaccumulationinbreastcancercells[1].2′-Hydroxychalcone(30μM;24h)inducesautophagy-dependentapoptosisinbreastcancercells,andincreasescleavageofcaspase-3andPARP[1].2′-Hydroxychalcone(10-30μM;24h)significantlyreducestheexpressionofp-IκBandp-NF-κBp65,andelevatesthelevelsofp-ERKandp-JNK[1].2′-Hydroxychalcone(30μM;12-24h)increasedtheintracellularROSlevelsandtriggeredendoplasmicreticulumstress(ERS)ofbreastcancercells[1].CellViabilityAssay[1]CellLine:MCF-7andCMT-1211cellsConcentration:10μM,20μM,30μM,40μM,50μM,60μM,70μM,80μM,and90μMIncubationTime:12h,24h,36h,48h,60h,and72h1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Suppressedcellviabilityinadose-dependentmanner.CellAutophagyAssay[1]CellLine:MCF-7andCMT-1211cellsConcentration:10μM,20μM,30μMIncubationTime:24hResult:Inducedautophagyandpromotedautophagyfluxinbreastcancercells.ApoptosisAnalysis[1]CellLine:MCF-7andCMT-1211cellsConcentration:30μMIncubationTime:24hResult:Inducedautophagy-dependentapoptosisofbreastcancercells.WesternBlotAnalysis[1]CellLine:MCF-7andCMT-1211cellsConcentration:10μM,20μM,30μMIncubationTime:24hResult:RegulatedMAPK/NF-κBsignalingpathwaysandinhibitedmigration/invasionofbreastcancercells.体内研究2'-Hydroxychalcone(20-60mg/kg;ip;every2days;3weeks)couldexhibitanantitumoreffectinvivowithoutcausingsignificanttoxicitytoessentialorgans[1].AnimalModel:Five-week-oldBalb/CfemalemiceinjectedwithCMT-1211cells[1]Dosage:20mg/kg,40mg/kg,60mg/kgAdministration:Intraperitonealinjection;every2days;3weeksResult:Suppressedtumorgrowthandmetastasisinvivo.REFERENCES[1].KailaPMedina-Alarcón,etal.Antifungalactivityof2'-hydroxychalconeloadedinnanoemulsionagainstParacoccidioidesspp.Future2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEMicrobiol.2020Jan:15:21-33.[2].XiaoWang,etal.2'-HydroxychalconeInducesAutophagyandApoptosisinBreastCancerCellsviatheInhibitionoftheNF-κBSignalingPathway:InVitroandInVivoStudies.Nutrients.2024Feb13;16(4):514.McePdfHeightCaution:Producthasnotbeenfullyvalidatedfor