四年级上册品德与社会课件-《集体力量大》1-浙教版

AutoimmunityandAutoimmuneDiseasesGuangjieChenDept.ofImmunologyandMicrobiology2014AutoimmunityandAutoimmuneDiAutoimmunityisdefinedasanacquiredimmunereactivityagainstselfantigensThenormalphysiologicalactivityessence

----autoimmuneresponseAutoimmunityisdefinedasanAutoimmunediseasesoccurwhenautoimmuneresponsesleadtotissuedamageTheabnormalphysiologicalactivityessence----autoimmuneresponseAutoimmunediseasesoccurwhenBreakingofself-toleranceEhrlich’s“Horrorautotoxicus”Breakingofself-toleranceEI.ThecharacteristicsandclassificationofAIDI.Thecharacteristicsandcl1.TheessentialcharacteristicsofAIDautoantibody，Self-reactiveTcellsLeadtotissuedamageanddysfunctionTheprognosisiscloselyrelatedtotheintensityoftheautoimmuneresponserecurrepeatedly,chronicprolongedfemaleheredity1.Theessentialcharacteristi2.ClassificationofAIDOrganspecific

IDDM、MSNon-organspecific

SLE、RA2.ClassificationofAID四年级上册品德与社会课件-《集体力量大》1-浙教版II.TheimmunedamagemechanismofAID1.Theeffectofautoantibodybindingtocellmembrane2.TheeffectofautoantibodytomembranereceptorTheeffectofautoantibodytoponentsTheeffectofplexdeposition5.TheeffectofautoreactiveTcellII.TheimmunedamagemechaniTypeIIhypersensitivity（1，2，3)Theeffectofautoantibodybindingtocellmembrane

（IgM、IgG）Autoimmunehemolyticanemiathrombopenicpurpura

HemolyticdiseaseofthenewborninducedbyRhincompatibilityTypeIIhypersensitivity（1，2，3四年级上册品德与社会课件-《集体力量大》1-浙教版四年级上册品德与社会课件-《集体力量大》1-浙教版The

effectofautoantibodytomembranereceptorMyastheniagravisGraves

diseaseTheeffectofautoantibodyto四年级上册品德与社会课件-《集体力量大》1-浙教版ThyroidepithelialcellTSH-RTSHT3、T4Anti-TSH-RAbThyroidTSH-RTSHT3、T4Anti-TSH-Figure13-29part1of2Figure13-29part1of23.TheeffectofautoantibodytoponentsGoodpasturessyndrome3.Theeffectofautoantibody医学免疫学上海第二医科大学免疫教研室*antibasementmembrane（kidney,lung）typeIVcollagenAb医学免疫学上海第二医科大学免疫教研室*antibasem4.Theeffectofplexdeposition*TypeIIIhypersensitivity4.Theeffectofplexdepositi(1)SLE(1)SLE（2）RA(2)RA（2）RA(2)RA5.TheeffectofautoreactiveTcell*TypeIVhypersensitivityMultiplesclerosis(MS） Th1、Tc、MBPTypeIdiabetesmellitusTc→β

cell5.Theeffectofautoreactive四年级上册品德与社会课件-《集体力量大》1-浙教版四年级上册品德与社会课件-《集体力量大》1-浙教版四年级上册品德与社会课件-《集体力量大》1-浙教版III.PathogenicfactorsrelatedtoAIDAntigen-relatedfactorsReleasingofsequesteredantigenAlterationofselfantigenpropertiesMolecularmimicry

commonantigen→crossreaction

streptococcus—kidney,heart

III.Pathogenicfactorsrelate2.AbnormalitiesofimmuneregulationAbnormalexpressionofMHC-IIBreaktheimmunologicalignorance

DysfunctionofTregAbnormalexpressionofFas/FasLActivationofTandBclonesEpitopespreading 2.Abnormalitiesofimmunereg四年级上册品德与社会课件-《集体力量大》1-浙教版四年级上册品德与社会课件-《集体力量大》1-浙教版AutoantigensAutoantigeninducedTcellexpansionAutoimmunelymphoproliferativesyndrome,ALPSAutoantigensAutoantigeninduce四年级上册品德与社会课件-《集体力量大》1-浙教版四年级上册品德与社会课件-《集体力量大》1-浙教版HLA-DR3 Myasthenisgravis,SLEHLA-DR4 RA、TypeIdiabetesHLA-B27 Ankylosingspondylitis3.HeredityfactorsAssociationbetweenHLA

allelsanddiseasesHLA-DR3 Myasthenisgravis,SLE四年级上册品德与社会课件-《集体力量大》1-浙教版Othergenes

C1q,C4

genedeficiency：SLE

DNasedeficiency

：SLE

mutantCTLA-4：DiabetesSexOthergenesIV.TreatmentofAIDControlinfectionAdministrationofimmunosuppressivedrug ControlinflammationCytokine IL-4→MSAntibodies

anti-TNF-α RA

anti-CD4 RA anti-MHCII SLE、RAIV.TreatmentofAIDControlin四年级上册品德与社会课件-《集体力量大》1-浙教版AutoreactiveT

cellSynovialfibroblastM

IFN-,IL-17IL-1,IL-15IL-1,TNF-ChondrocyteOsteoclastMMPs,IL-6,IL-8,GM-CSFCartilageandbonedestructionTNFinhibitorsIL-1inhibitorIL-6inhibitorOraltoleranceTcellvaccineMMPsTcellcostimulatoryblockersAutoreactiveSynovialfibroblasTargetNameoftherapeuticProductofdescriptionStageofdevelopmentCurrentTNF-

EtanerceptSolublep75TNFR–humanIgG1FcfusionproteinLisencedInfliximabChimericmAbspecificforTNF-

LisencedAdalimumabHumanizedmAbspecificforTNF-αLisencedIL-1AnakinraIL-1raLisencedIL-6TocilizumabHumanizedmAbspecificforIL-6RPhaseIIIclinicaltrialsInperspectiveIL-1AMG108HumanizedmAbspecificforIL-1βPhaseIIclinicaltrialsIL-15HuMaxIL-15(AMG714)HuMaxIL-15(AMG714)PhaseIIclinicaltrialsIL-17LubbertsE(2