临床药物评价

钟宝琳，黄桂明，李以平，陈以建，李优春Clinicalanalysisofdexmedetomidineinintraoperativewake-uptestduringlanguagefunctionalsurgerywithnarcotrendmonitorZHONGBao-lin,HUANGGui-ming,LIYi-ping,CHENYi-jian,LIYou-chun（DepartmentofAnesthesiology,ThePeople’sHospitalofGanzhou,Ganzhou

排除标准东嘉博制药有限公司生产；盐酸瑞芬太尼注射液，规格:每支1mg，批号：6140405，宜昌人福药业有限责任公司生产。持续测压。以盐酸戊乙奎醚0.02㎎㎏-1、咪达唑仑1㎎、丙泊酚2㎎㎏-1、罗库溴铵0.8㎎㎏-1诱导，插入喉罩，通气满意后以丙泊酚4μg·mL-1，瑞芬太1min-sxsControlGender41.29土41.17土2T0、T1、T2T3、T4血压、心率差异无统计学意(>0.05)，试验组T5T6和T7血压、心率明显低于对照组（P<0.05），2组各时点N值差异无统计学意义（P0.5）。2T5、6和7（>0.0），2组4N2。表2唤醒前及唤醒期间情况对比（sTable2Comparisonbeforewake-upandduringwake-

xsControlControlControlControlControl5ControlT0:Atthebeginningofanesthesia;T1:Beforecutskin;T2:Whenthecraniotomy;T3:Wakeingup;T4andT5:Atevery5minbefore10minofthebeginningofwakeingup;T6:10minbeforetheendofwakeingup;T7:Theendofwakeingup;Comparedwithcontrolgroup,*P<0.05)RozetI.Anesthesiaforfunctionalneurosurgery:theroleofdexmedetomidine[J].Curr Anaesthesiol,2008,21:537-GaravagliaMM,DasS,CusimanoMD,etal.Anestheticapproachtohigh-riskpatientsandprolongedawakecraniotomyusingdexmedetomidineandscalpblock[J].JNeurosurgAnaesthesiol,2014,26:226-233.范凤飞.[J].实用医学杂志2012,28:1174-黎平.[J].临床麻醉学杂志2011,27:755-FaragE,ArgaliousM,Abd-elsayedA,etal.Theuseofdexmedetomidineinanesthesiaandintensivecare:areview[J].CurrPharmDes,2012;18:6257-ShenSL,ZhengJY,ZhangJ,etal.Comparisonofdexmedetomidineandpropofolforconscioussedationinawakecraniotomy:aprospective,double-blind,randomized,andcontrolledclinicaltrial[J].AnnPharmacother,2013,47:1391-1399.KreuerS,BiedlerA,LarsenR,etal.Narcotrendmonitoringallowsfasteremergenceandareductionofdrugconsumptioninpropofol-remifentanilanesthesia[J].Anesthesiol,2003,99:34-41.RinöslH,FleckT,DworschakM.BrainischemiainstantaneouslytrackedbythenarcotrendEEGdevic