MARK4-inhibitor-2-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMARK4inhibitor2Cat.No.:HY-154986分⼦式:C₃₄H₃₀N₄O₃分⼦量:542.63作⽤靶点:AMPK作⽤通路:Epigenetics;PI3K/Akt/mTOR储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性MARK4inhibitor2微管亲和调节激酶4(MARK4)的抑制剂，对其Km值为6.3×107，IC50为0.82μM。MARK4inhibitor2抑制癌细胞的⽣长，可⽤于癌症研究。IC50&TargetIC50:0.82μM(MARK4)[1]Km:6.3×107[1]体外研究MARK4inhibitor2(Compound23a)(0-20μM;24hour)inhibitsthegrowthofHeLa,U87MG,MDA-MB-435,U251andHGFscellswithEC50srangingfrom1.76μMto7.98μM[1].CellViabilityAssay[1]CellLine:HeLa,U87MG,MDA-MB-435,U251,HGFscellsConcentration:0-20μMIncubationTime:24hoursResult:InhibitedthegrowthofhumancellswithEC50sof2.13,4.13,1.76,7.98,3.55μMforHeLa,U87MG,MDA-MB-435,U251,HGFscells,respectively.Decreasedtheproliferationofhumancancercellsinthelowmicromolarrange;alsoaffectsthenon-cancerousHGFcells.REFERENCES[1].MariaVoura,et.al.Synthesis,StructuralModification,andBioactivityEvaluationofSubstitutedAcridonesasPotentMicrotubuleAffinity-RegulatingKinase4InhibitorsACSPharmacology&TranslationalScience20236(7),1052-1074.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02