Curcumin-5-8-CUR5-8-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECurcumin5-8Cat.No.:HY-148598CASNo.:890984-26-6Synonyms:CUR5-8分⼦式:C₂₀H₂₁NO₄分⼦量:339.39作⽤靶点:Apoptosis;Autophagy作⽤通路:Apoptosis;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Curcumin5-8(CUR5-8)⼀种天然活性姜素(CUR)类似物。Curcumin5-8抑制脂滴形成。Curcumin5-8促进细胞⾃噬(autophagy)并抑制细胞凋亡(Apoptosis)。Curcumin5-8改胰岛素抵抗和胰岛素敏感性[1]。体外研究Curcumin5-8(20µM;24h)decreasesPA(palmiticacid(HY-N0830))-inducedSREBP1expressionlevelsandincreasesBcl2/BAXexpressioninAML12cells[1].WesternBlotAnalysis[1]CellLine:AML12cellsConcentration:20µMIncubationTime:24hResult:SignificantlydecreasedPA-inducedSREBP1expressionlevels,increasedBcl2/BAXexpression.体内研究urcumin5-8(100mg/kg;diet;dailyfor13weeks)amelioratesinsulinresistanceandhepaticsteatosisinmicewithHFD(high-fatdiet)-inducedobesity[1].AnimalModel:6-week-oldmales,20g,C57BL/6mice[1]Dosage:100mg/kg1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAdministration:Diet;dailyfor13weeksResult:SignificantlysuppressedtheincreasesintheinsulinlevelandHOMA-IR.REFERENCES[1].LeeES,etal.CurcuminanalogCUR5-8amelioratesnonalcoholicfattyliverdiseaseinmicewithhigh-fatdiet-inducedobesity.Metabolism.2020Feb;103:154015.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax