Compound-C108-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECompoundC108Cat.No.:HY-131649CASNo.:15533-09-2分⼦式:C₁₅H₁₄N₂O₃分⼦量:270.28作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:25mg/mL(92.50mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.6999mL18.4993mL36.9987mL5mM0.7400mL3.6999mL7.3997mL10mM0.3700mL1.8499mL3.6999mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性CompoundC108⼀种G3BP2抑制剂。CompoundC108也靶向应激颗粒相关蛋⽩、GTPase激活蛋⽩(SH3结构域)结合蛋⽩2。CompoundC108显著抑制⾷管鳞状细胞癌(ESCC)细胞转移。IC50&TargetG3BP2[1]体外研究CompoundC108(1μM;24h)showsanti-tumoractivityagainstBT474cells[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECompoundC108(4μM;24h)significantlydecreasestheproteinexpressionofG3BP2inG3BP2overexpressingKYSE410cellsandLINC01554transfectedKYSE30cells[2].CompoundC108(4μM;24h)attenuatesESCCcellmetastasis,migrationandinvasioninKYSE410,KYSE30andKYSE150cells[2].WesternBlotAnalysis[2]CellLine:G3BP2-overexpressingKYSE410cells,LINC01554-transfectedKYSE30cellsConcentration:4μMIncubationTime:24hResult:DecreasedtheproteinlevelofG3BP2andHDGF.体内研究CompoundC108(1μM;24h)targetsanddecreasestumorinitiatingcells(TICs),whileinjectedBT-474cellstreatedwithCompoundC108intothemammaryfatpadoffemalenonobesediabetic/severecombinedimmunedeficiency(NOD-SCID)miceinalimiting-dilutionxenograftassay[1].REFERENCES[1].GuptaN,etal.Stressgranule-associatedproteinG3BP2regulatesbreasttumorinitiation.ProcNatlAcadSciUSA.2017Jan31;114(5):1033-1038.[2].ZhengY,etal.G3BP2regulatedbythelncRNALINC01554facilitatesesophagealsquamouscellcarcinomametastasisthroughstabilizingHDGFtranscript.Oncogene.2022Jan;41(4):515-526.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te