(24)-执业药师药剂学Preparationofointments

IV.Preparationofointments采用新生皂法制备雪花膏，并用两相交替加入法制备W/O型乳膏剂基质，并计算混合乳化剂的HLB值。PurposeTomasterthepreparationofdifferentkindsofbasesofointments.Equipmentsandmaterials1.EquipmentsEvaporatingdish,waterbath,electricfurnace,analyticalbalance,thermometer,microscopeetc.2.MaterialsStearicacid,glycerolmonostearate,vaseline,giycerol,liquidparaffin,triethanolamine,calciumhydroxide,cmc-na,span80,nonoxynol-10,distilledwateretc.Procedures1.O/Wemulsionbase(1)FormulationStearicacid4.8gGlycerolmonostearate1.4gLiquidparaffin2.4gVaseline0.4gWoolfat0.16gDistilledwateraddupto40.0g(2)PreparationAddstearicacid,glycerolmonostearate,liquidparaffin,Vaselineandwoolfatintoevaporatingdish,whichthemixtureisusedasoilphase.Addtrithanolamineanddistilledwaterintobeaker,whichthesolutionisusedaswaterphase.Thetwocontainersareheatedto80℃inwaterbathandkeptuntilmeltingcompletely.Pouroilphaseintowaterphaseslowly,andstirthemfully.Coolatroomtemperature,thentheO/Wemulsionbasecanbegot.2.W/OemulsionbaseI(1)FormulationGlycerolmonostearate0.85gBeeswax50.2gParaffin3.75gStearicacid0.625gLiquidparaffin20.5gVaseline3.35gAluminumdistearate0.5gCalciumhydroxide0.05gEthylparaben0.1gDistilledwater20.0gEssenceappropriateamountpreparationAddglycerolmonostearate,beeswax,paraffinandstearicacidintotheevaporatingdishthatisabovewaterbath.whenthemixtureismelted,addVaseline,liquidparaffinandaluminumdistearateintoit.Theabovemixtureisusedastheoilphase.Calciumhydroxideandethylparabenaredissolvedindistilledwater.Thedegreeofwaterisabout80℃thesolutionisusedasthewaterphase.Aclockwisestirringisneededwhenaddwaterphaseintooilphase.Coolthebasetoroomtemperature,thentheW/Oemulsionbasecanbegot.3.W/OemulsionbaseIIFormulationHLBGlycerolmonostearate4.0g3.8Paraffin4.0g4.0Liquidparaffin20.0g4.0Vaseline2.0g5.0Span800.1g4.3Nonoxynol-100.2g15.0Chlorocresol0.04gDistilledwater10.0gpreparationAddglycerolmonostearateandparaffinintotheevaporatingdishthatisabovethewaterbath.Thenaddvaseline,liquidparaffin,span80intothisevaporatingdish.Thismixtureisusedastheoilphase.Nonoxynol-10andchlorocresolaredissolvedindistilledwater.Thissolutionisusedasthewaterphase.Keeptheoilandwaterphaseatatemperatureof80℃.Addthewaterphaseintotheoilphasewithclockwisestirring.Coolthemixture,thentheW/Oemulsionbasecanbegot.4.EvaluationordeterminationonointmentsIdentificationofthestylesoftheemulsionbaseStabilitytestBasecompatibilitytestQuestionsWhatistheemulsifyingagentinO/Wemulsionointmentbase?Howabouttheappearanceandstabilityoftheemulsionointmentbasecontainingmonatomicsoapaccordingtotheexperimentalresults?WhatistheemulsifyingagentinthefirstformulationofW/Oemu