HLF1-11-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEHLF1-11Cat.No.:HY-106228CASNo.:183623-03-2分⼦式:C₅₆H₉₅N₂₅O₁₄S分⼦量:1374.58SequenceShortening:GRRRRSVQWCA作⽤靶点:Fungal;Bacterial;GlutathionePeroxidase作⽤通路:Anti-infection;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性HLF1-11，⼀种⼈乳铁蛋⽩衍⽣肽，⼀种⼴谱抗剂。HLF1-11抑制MPO(human)的活性。HLF1-11还使GM-CSF驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。体外研究hLF1-11(1,10,and100μg/mL)directsdifferentiationofmonocytestowardamacrophagesubsetduringgranulocyte-macrophagecolony-stimulatingfactor(GM-CSF)-drivenmonocytesdifferentiation[2].hLF1-11(0.5-250μg/mL)inhibitshumanMPOactivity[3].hLF1-11(100μg/mL,90min)inhibitsROSinductioninducedbyLPSinmonocytes[3].hLF1-11(8-34μΜ,2h)isactiveagainstfluconazole-resistantC.albicans[5].体内研究hLF1-11(20mg/kg,injectedintothedebridedtibialcavity)showsabilityagainstMRSAosteomyelitisinrabbits[4].hLF1-11(40μg/kg,i.v.)isactiveagainstC.albicans-infectedmice[6].AnimalModel:RabbitsinoculatedwithCFUMRSA[4]Dosage:20mg/kgAdministration:InjectedintothedebridedtibialcavityResult:Reducedbacterialloadcomparedtocontrols,andreducedtheradiologicalandhistopathologicalscore.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAnimalModel:Neutropenicmicechallengedi.v.withC.albicansDosage:40μg/kgAdministration:Intravenousinjection(i.v)Result:ReducedserumTNFαandIL-6ininfectedmice.REFERENCES[1].MartyWulferink,etal.ThePeptidehLF1-11asBroadSpectrumAntmicrobialProphylaxisinHSCTPatients.Blood(2005)106(11):3241.[2].vanderDoesAM,etal.AntimicrobialpeptidehLF1-11directsgranulocyte-macrophagecolony-stimulatingfactor-drivenmonocytedifferentiationtowardmacrophageswithenhancedrecognitionandclearanceofpathogens.AntimicrobAgentsChemother.2010Feb;54(2):811-6.[3].vanderDoesAM,etal.Thehumanlactoferrin-derivedpeptidehLF1-11exertsimmunomodulatoryeffectsbyspecificinhibitionofmyeloperoxidaseactivity.JImmunol.2012May15;188(10):5012-9.[4].FaberC,etal.Comparableefficaciesoftheantimicrobialpeptidehumanlactoferrin1-11andgentamicininachronicmethicillin-resistantStaphylococcusaureusosteomyelitismodel.AntimicrobAgentsChemother.2005Jun;49(6):2438-44.[5].LupettiA,etal.CandidacidalactivitiesofhumanlactoferrinpeptidesderivedfromtheNterminus.AntimicrobAgentsChemother.2000Dec;44(12):3257-63.[6].upettiA,etal.Humanlactoferrin-derivedpeptide'santifungalactivitiesagainstdisseminatedCandidaalbicansinfection.JInfectDis.2007Nov1;196(9):1416-24.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapp