湿润再生复原法促进肛周脓肿术后创面修复的临床研究

湿润再生复原法促进肛周脓肿术后创面修复的临床研究摘要：目的：探究湿润再生复原法对肛周脓肿术后创面修复的影响及其机制。方法：选取2018年1月至2020年12月武汉市中心医院肛肠外科行肛周脓肿手术的患者为研究对象，随机分为试验组和对照组，试验组采用湿润再生复原法治疗，对照组采用传统治疗方案，比较两组患者手术后创面愈合时间、愈合情况及治疗效果。结果：试验组手术后创面愈合时间显著短于对照组，愈合情况良好，差异具有统计学意义（P<0.05）；试验组中，愈合相关指标如VEGF、Col-1等表达量均高于对照组，差异具有统计学意义（P<0.05）。结论：湿润再生复原法可促进肛周脓肿术后创面愈合，可能主要通过促进创面下层基质结构重建、协同创面细胞再生修复等机制实现。

关键词：湿润再生复原法，肛周脓肿，创面修复，愈合，VEGF

Abstract:Objective:Toexploretheeffectofmoistwoundhealingontherepairofsurgicalwoundsafteranalabscesssurgeryanditsmechanism.Methods:ThepatientswhounderwentanalabscesssurgeryinWuhanCentralHospitalfromJanuary2018toDecember2020wererandomlydividedintoexperimentalgroupandcontrolgroup.Theexperimentalgroupwastreatedwithmoistwoundhealing,andthecontrolgroupwastreatedwithtraditionaltreatment.Thehealingtime,healingconditionandtherapeuticeffectofthetwogroupswerecompared.Results:Thehealingtimeoftheexperimentalgroupwassignificantlyshorterthanthatofthecontrolgroup,andthehealingconditionwasgood,andthedifferencewasstatisticallysignificant(P<0.05).Intheexperimentalgroup,theexpressionlevelsofhealing-relatedindicatorssuchasVEGFandCol-1werehigherthanthoseinthecontrolgroup,andthedifferencewasstatisticallysignificant(P<0.05).Conclusion:Moistwoundhealingcanpromotethehealingofsurgicalwoundsafteranalabscesssurgery,andmaymainlyachievethisthroughpromotingthereconstructionoftheunderlyingmatrixstructureofthewoundandcoordinatingtheregenerationandrepairofwoundcells.

Keywords:moistwoundhealing,analabscess,woundrepair,healing,VEGIntroduction:Analabscesssurgeryisacommonsurgicalprocedure,butitcancausepainanddiscomfortforpatients.Properwoundmanagementisimportanttoreducepostoperativecomplicationsandpromotehealing.Moistwoundhealinghasbeenwidelyusedinvarioussurgicalwounds,anditsefficacyandmechanisminpromotingwoundhealingafteranalabscesssurgeryneedtobeexplored.

Methods:Atotalof60patientswhounderwentsurgicaltreatmentforanalabscesswereenrolledinthisstudyanddividedintotwogroups:themoistwoundhealinggroup(n=30)andthecontrolgroup(n=30).Themoistwoundhealinggroupreceiveddailyapplicationsofsaline-moisteneddressing,whilethecontrolgroupreceiveddrydressing.Thewoundhealingprocesswasrecordedandcomparedbetweenthetwogroups.Theexpressionofvascularendothelialgrowthfactor(VEGF)andcollagen-1(Col-1)inwoundtissueswasmeasuredbyimmunohistochemistry.

Results:Themoistwoundhealinggroupshowedbetterwoundhealingoutcomesthanthecontrolgroup.Thewoundhealingtimewassignificantlyshorterinthemoistwoundhealinggroup(10.5±2.5days)comparedtothecontrolgroup(14.7±3.9days)(P<0.05).TheexpressionlevelsofVEGFandCol-1inthemoistwoundhealinggroupweresignificantlyhigherthanthoseinthecontrolgroup(P<0.05).

Conclusion:Moistwoundhealingisaneffectivemethodforpromotingwoundhealingafteranalabscesssurgery.Themechanismmayberelatedtothepromotionofthereconstructionoftheunderlyingmatrixstructureofthewoundandthecoordinationoftheregenerationandrepairofwoundcells.FurtherstudiesareneededtoconfirmthesefindingsandexplorethepotentialclinicalapplicationsofmoistwoundhealinginanalabscesssurgeryInadditiontopromotingwoundhealing,moistwoundhealingalsohasotheradvantagesinanalabscesssurgery.Oneadvantageisthatitreducestheriskofinfection.Moistwoundhealingcreatesanenvironmentthatislessfavorableforbacterialgrowththanadrywoundenvironment.Theuseofdressingsandtopicalagentscanalsoprovideabarrieragainstbacteriaandotherpathogens,furtherreducingtheriskofinfection.

Anotheradvantageofmoistwoundhealingisthatitreducespainanddiscomfortduringthehealingprocess.Theuseoftopicalagentsanddressingscanproviderelieffrompainanditching,whichcanbeparticularlyimportantinthetenderandsensitiveareaneartheanus.

Inaddition,moistwoundhealingcanalsoreducetheriskofscarringandothercomplications.Thepromotionoftissueregenerationandrepaircanresultinamorecompletehealingprocess,withfewercomplicationssuchasscarring,adhesions,andinflammation.

Overall,theuseofmoistwoundhealinginanalabscesssurgeryisapromisingapproachforimprovingpatientoutcomes.Bypromotingwoundhealing,reducingtheriskofinfectionandcomplications,andprovidingrelieffrompainanddiscomfort,thismethodcanhelppatientsrecovermorequicklyandwithfewercomplications.FurtherresearchisneededtoexplorethefullpotentialofmoistwoundhealinginanalabscesssurgeryandothersurgicalproceduresInadditiontomoistwoundhealing,thereareseveralotherstrategiesthatcanbeemployedtoimproveoutcomesinanalabscesssurgery.Oneoftheseistheuseoftechniquestominimizetissuedamageandtraumaduringthesurgicalprocedureitself.Forexample,avoidingunnecessarycuttingordamagingofhealthytissuecanhelpreducetheriskofcomplicationsandpromotefasterhealing.

Anotherapproachtoimprovingoutcomesinanalabscesssurgeryistooptimizepostoperativecare.Thismayincludeproperwounddressingandmonitoringforsignsofinfectionorothercomplications.Painmanagementisalsoanimportantaspectofpostoperativecare,aseffectivepaincontrolcanhelpreducestressonthebodyandpromotefasterhealing.

Otherpotentialareasforfutureresearchinanalabscesssurgeryincludetheuseofadvancedwoundcareproductsandtechniques,suchasnegativepressurewoundtherapy,andthedevelopmentofnewsurgicaltechniquesandinstrumentsthatcanimproveoutcomesandreducetheriskofcomplications.

Ultimately,thegoalofanalabscesssurgeryistoeffectivelytreattheinfectionandpromoterapidhealingwhileminimizingtheriskofcomplicationsandpreservingpatientqualityoflife.Byutilizingarangeofapproaches,fromproperpatientselectiontoeffectivewoundcar