(3.1)-20200415-干法粉碎和湿法粉碎-英文版

Part1PulverizationPharmaceuticsofTCMPulverizationpowderMargaritapowderBoviscalculusPulverizationistheprocessofbreakinglargepiecesofsolidmaterialintodesiredsizebymechanicalforceorothermeans.1

Toincreasethesurperficial

area,promotethedissolutionandabsorption,andimprovethebioavailabilityofdrugs.2Beconvenientfordivideddose,preparationandtaking.3

Infavorofextractionordissolutionoftheeffectiveingredients.4

Tolayafoundationforthepreparationofvariousliquidandsoliddosageforms.ThepurposeofcrushingPulverizationDry

grindingWet

grindingCryogenicgrindingSuperfinegrindingMethodsofpulverizationPulverizationDrypulverization:Itreferstoamethodinwhichthemoistureinadrugisreducedtoacertainlimit(usuallylessthan5%).PulverizationDrynessCrushedmaterialMedicinePulverizationMixedpulverizationPulverizeseparately（Danyan）PulverizeseparatelyValuableChinesemedicineAntelopehornBoviscalculusMoschusPulverizationToxicorirritatingChinesemedicineVenenumbafonisCalomelasCantharidesPulverizationPulverizeseparatelyStrongoxidizingandreducingChinesemedicineRealgarNitroumSulphurPulverizationPulverizeseparatelyChinesemedicinewithhardtexture,whichisdifficulttocrush.MagnetitumRaddlePulverizationPulverizeseparately10MixCrushedmaterialMedicinePulverizationMixedpulverizationPulverizationClustermaterialcrushingSteamingcrushingStringoilpulverization11METHOD：Firstly,othertraditionalChinesemedicinesintheprescriptioncanbecrushedintocoarsepowder,andthentheviscousherbsareadded,graduallycrushedtotherequiredparticlesize.Themedicinalmaterialscontainingalotofsugar,resin,gum,mucusareconsistedinoneprescription.LyciifructusRehmanniae

radixpraeparataPolygonatirhizomaPohipopgonisradixClustermaterialcrushingPulverization12METHOD：Firstly,othertraditionalChinesemedicinesintheprescriptioncanbecrushedintocoarsepowder,andthenthiskindofmedicinalmaterialswerejoining,graduallycrushedintotherequiredparticlesize.StringoilpulverizationThemedicinalmaterialscontainingalargenumberoffattyingredientsareconsistedinoneprescription.PersicaesemenZiziphispin-osaesemenPerillae

fructusArmeniacaesemenamarumPulverization13METHOD：Generally,theotherChinesemedicineintheprescriptionisfirstlycrushedintocoarsepowder,andthenthecoarsepowderismixedwiththemedicinethathasbeensteamedwithappropriatemethods,finally,crushingthemtogetherintotherequiredparticlesizeafterdrying.SteamingcrushingChinesemedicineswhichareanimalskins,meat,tendons,bones,andsomeplantmedicinesthatneedtobesteamedareconsistedinoneprescription.DeerfetusGinseng

radix

et

rhizoma

rubraPolygoni

multiflori

radix

praeparataScutellariaeradixwithwinePulverizationWetgrinding:Itreferstheprocessofaddinganappropriateamountofwaterorotherliquidtogrindtogether.▪Noinflation▪NointerferencewithefficacyWater/FluidCrushed

materialMedicinePulverizationPulverizationTheycanpenetrateintothecracksofmedicine,reducingthecohesionbetweenmoleculesWetgrinding----WaterflightmethodIt’samethodofgrindingtheinsolubledrugrepeatedlytotherequiredparticlesizebyusingthesuspensiondifferenceoffineandcoarsepowderinlargeamountsofwater.PulverizationChinesemedicinecontainingminerals,shellfishCinnabarisCalaminaMargarita

WaterflightmethodFreemercuryisremoved,soitstoxicityisreduced,whichisconvenientforpreparationandadministration.PulverizationWetgrinding-----FluidLappingIt’stheprocessofaddingasmallamountofliquidtoacrusheddrugandgrindingittoadesiredsize.SuchasCamphor、Borneolum、l-Menthol、Moschusandsoon.CamphorBorneolum

FluidLappingPulverization

MattersneedingattentioninpulverizationProperty

of

medicinevaluablevolatileMoschusBorneolumLightlygrindBorneolumHeavilygrindMoschus“DaChao”waterPulverizationWujiBaifengWanBlackchicken(shornchicken)640gCervi

Cornus

Colla

128gTrionycis

Carapax64gOstreaeConcha

48gMantidis

ootheca

48gGinsengRadixetRhizoma

128gAstragall

Radix

32gAngelicae

Sinensis

Radix

144gPaeoniae

Radix

Alba

128gAsparagi

Radix

64gGlycyrrhizae

Radix

et

Rhizoma

32gCyperi

Rhizoma(with

rice

vinegar)128gRehmanniaeRadix

256gRehmanniaeRadixPraeparata

256gChuanxiong,Rhizoma

64gStellariaeRadix26gSalviaeMiltiorrhizaeRadixetRhizoma128gDioscoriaeRhizoma

128gEuryalesSemen

(fry)64gCerviCornuDegelatinatum

48g

PulverizationClassic

caseFormulationWujiBaifengWanPulverizationClassic

casePreparationCrush,place

in

the

tank,coverandstewthewinetillexhaustedRehmanniae

Radix,RehmanniaeRadixPraeparata,Chuanxiong,Rhizoma,Stellariae

Radix,Salviae

MiltiorrhizaeRadixetRhizoma,Dioscoriae

Rhizoma,EuryalesSemen,CerviCornu

Degelatinatum

GrindCourse

powderTheothertwelveingrdients

DryatalowertemperaturePulverizeFine

powderSiftMixthoroughlyMakepillsPillsYellowricewine1500gJiu

Yi

SanClassic

caseGrindWater

flightGrind

and

siftGypsum

Ustum

900gHydrargyri

Oxydum

Rubrum100gUltra

fine

powderUltrafinepowderFinished

productPulverizationWater

flightSteamer（compoundandcompatibility）PulverizationSummaryDry

grindingPulverizate

separatelyMixedpulverizationWaterflight