1V209-TLR7-agonist-T7-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE1V209Cat.No.:HY-115400CASNo.:1062444-54-5Synonyms:TLR7agonistT7分⼦式:C₁₆H₁₇N₅O₅分⼦量:359.34作⽤靶点:Toll-likeReceptor(TLR)作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:83.33mg/mL(231.90mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.7829mL13.9144mL27.8288mL5mM0.5566mL2.7829mL5.5658mL10mM0.2783mL1.3914mL2.7829mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(5.79mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.79mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性1V209(TLR7agonistT7)Toll-likereceptor7(TLR7)激动剂，具有抗肿瘤作⽤。1V209可与各种多糖缀合，以改其⽔溶性，增强功效并保持低毒性。IC50&TargetTLR7体外研究1V209(0.1-10μM)treatmentsignificantlystimulatesTNFαproductioninRAW246.7cells[1].1V209(18hours)treatmentincreasesIL-6productioncomparainbonemarrowderiveddendriticcells[1].体内研究Theintravenous(IV)administrationoftheformulationtomicebearing4T1breastcancertumorsresultsinnanoparticleaccumulationintumors,reductioninprimarytumorgrowth,andinhibitionoflungmetastases,ascomparedtosaline-treatedanimals.Miceadministered1V209experiencesignificantlyincreasesplasmalevelsofproinflammatorycytokinesIL-6,IP-10,andMCP-1at2hfollowingIVadministration[1].户使⽤本产品发表的科研⽂献•Nanomedicine.2022Jun18;102573.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BattistellaC,etal.DeliveryofImmunotherapeuticNanoparticlestoTumorsviaEnzyme-DirectedAssembly.AdvHealthcMater.2019Dec;8(23):e1901105.[2].ShinchiH,etal.EnhancementoftheImmunostimulatoryActivityofaTLR7LigandbyConjugationtoPolysaccharides.BioconjugChem.2015Aug19;26(8):1713-23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch