SLF-amido-C2-COOH-PROTAC-FKBP12-binding-moiety-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESLF-amido-C2-COOHCat.No.:HY-107452CASNo.:1092369-24-8Synonyms:PROTACFKBP12-bindingmoiety1分⼦式:C₃₄H₄₄N₂O₉分⼦量:624.72作⽤靶点:LigandsforTargetProteinforPROTAC;FKBP作⽤通路:PROTAC;Apoptosis;Autophagy;Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(160.07mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6007mL8.0036mL16.0072mL5mM0.3201mL1.6007mL3.2014mL10mM0.1601mL0.8004mL1.6007mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(4.00mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(4.00mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(4.00mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性SLF-amido-C2-COOH(PROTACFKBP12-bindingmoiety1)⼀种合成的FKBP配体(SLF)，可⽤于合成PROTAC分⼦。体外研究SLF-amido-C2-COOH(PROTACFKBP12-bindingmoiety1)isasyntheticligandforFKBP(SLF).SLFiscomposedofonlyonehalfofFK506anditisknowntohaveasignificantlyweakeraffinityforFKBP12[1].REFERENCES[1].DunyakBM,etal.SelectiveTargetingofCellsviaBispecificMoleculesThatExploitCoexpressionofTwoIntracellularProteins.ACSChemBiol.2015Nov20;10(11):2441-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379