IM-54-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIM-54Cat.No.:HY-108351CASNo.:861891-50-1分⼦式:C₁₉H₂₃N₃O₂分⼦量:325.4作⽤靶点:Others作⽤通路:Others储存⽅式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验DMSO:50mg/mL(153.66mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.0731mL15.3657mL30.7314mL5mM0.6146mL3.0731mL6.1463mL10mM0.3073mL1.5366mL3.0731mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(7.68mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(7.68mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性IM-54⼀种选择性的氧化应激诱导的坏死(necrosis)抑制剂。IM-54对H2O2诱导的坏死有强烈的抑制作⽤。IM-54⼀种潜在的⼼脏保护剂和研究细胞死亡分⼦机制的⽣物⼯具[1][2]。体外研究IM-54selectivelyinhibitsoxidativestress-inducednecrosis,butitdoesnotinhibitapoptosisinducedbyvariousanticancerdrugsorFasligand,ornecroptosis[1].IM-54showsstronginhibitionofH2O2-inducednecrosis,withanIC50of0.25μMinHL-60cells[1].REFERENCES[1].KosukeDodo,etal.IndolylmaleimideDerivativeIM-17ShowsCardioprotectiveEffectsinIschemia-ReperfusionInjury.ACSMedChemLett.2018Mar8;9(3):182-187.[2].MikikoSodeoka,etal.Developmentofselectiveinhibitorsofnecrosis.ChemRec.2010Oct;10(5):308-14.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37