Abeprazan-hydrochloride-DWP14012-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAbeprazanhydrochlorideCat.No.:HY-109079ACASNo.:1902954-87-3Synonyms:DWP14012hydrochloride;Fexuprazanhydrochloride分⼦式:C₁₉H₁₈ClF₃N₂O₃S分⼦量:446.87作⽤靶点:ProtonPump作⽤通路:MembraneTransporter/IonChannel储存⽅式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:100mg/mL(223.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2378mL11.1889mL22.3779mL5mM0.4476mL2.2378mL4.4756mL10mM0.2238mL1.1189mL2.2378mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Abeprazan(DWP14012)hydrochloride⼀种钾竞争性酸(potassium-competitiveacid)阻滞剂。Abeprazanhydrochloride通过可逆的钾竞争性离⼦结合抑制H+，K+-ATPase，⽽⽆需酸激活。Abeprazanhydrochloride⼀种潜在的质⼦泵抑制剂，⽤于研究与酸相关的疾病。体外研究ThemechanismofactionofAbeprazanhydrochlorideisreversiblybindingtoH+,K+1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE‐ATPase,and,unlikethatofPPIs,doesnotrequireacidicenvironmentfordrugactivation[1].体内研究Abeprazanhydrochloride(DWP14012hydrochloride)inhibitsacidsecretioninadose-dependentmannerandtheinhibitionofgastricacidsecretionisequaltoorgreaterthanthatofvonoprazan,apreviouslyapprovedP-CAB,invariousinvivostudiesusingpylorus-ligatedrats,lumen-perfusedratmodelsandheidenhainpouchdogmodels[1].REFERENCES[1].SunwooJ,etal.Safety,tolerability,pharmacodynamicsandpharmacokineticsofDWP14012,anovelpotassium-competitiveacidblocker,inhealthymalesubjects.AlimentPharmacolTher.2018Jul;48(2):206-218.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37