AOC第一章有机反应基本原理

AdvancedOrganicChemistryZhulili1985年，出生于湖北天门2004-2008年，西南大学化学化工学院2008-2013年，中国人民大学化学系2013至今，周口师范学院讲师。SelfIntroductionResearchInterest：OrganicSynthesis&OrganicReactionMethodology（1）金催化的一些新合成方法学的研究。（2）区域选择性N2烷基三唑的合成方法学研究。

电话有机化学有用有机合成物理有机有机分析合成一个新世界有机化学该怎么学？？？学习有机化学的难点：多，杂，规律性差是不是这个原因让人望而生畏，不全是!!!!!!有哪一种科学比记GRE单词更多，更杂，更没有规律性？？文献：<<Science>>,<<Nature>>与有机化学有关的一些期刊ACS系列:JournalofAmericanChemicalSocietyJournalofOrganicChemistryOrganicLettersOrganometallicsWieley系列:AngewChemieInternationaleditionChemistry,AEuropeanJournalChemistry,AAsianJournalEuropeanJournaloforganicChemistry

Rsc系列：ChemicalScience,ChemicalCommunicationElsevier系列：TetrahedronTetrahedronLettersTetrahedronAsymmetry检索工具：ScienceFinderBeilsteinCrossfireWebofScience有机化学的研究方法，学习方法

chemistry学习方法：youshouldremembersthinorganicchemistry,justlikestudyingalanguage.Howtolearn<<AdvancedOrganicChemistry>>.Thebasicrequirment:trytounderstandeachfigure,andtellyourselfwhatisgoingon.RememberBasicReactionsandtheirmechanismThereareseveralgeneralreactiontypesinorganictransformation,suchas:radicalreaction,polarreaction,andmetalcatalyzedreaction.

Therearesomeuniversaleffectsgoverningchemicalreactions,suchas:stericeffect,electroniceffect,etc.Trytoexplainthereactionphenomenonusingdifferentreactiontypesanddifferentreactionfactors.Trytopredictsomenewreaction,andthenverifyorfalsifyitthroughexperiments.

AccomplishmentsoforganicsynthesisinthetwentiethcenturyR.B.Woodward1917-1979介绍一些有机合成化学的大师1965NobelPrizeWinner.“forhisoutstandingachievementsintheartoforganicsynthesis.”SelectedsynthesesbytheWoodwardGroup(1944-1981).Ref:Angew.Chem.Int.Ed.2000,39,44–122.…Coreyhasthusbeenawardedwiththe1990nobelPrizeforthreeintimatelyconnectedcontributions,whichformawhole.Throughretrosyntheticanalysisandintroductionofnewsyntheticreactions,hehassucceededinpreparingbiologicallyimportantnaturalproducts,previouslythoughtimpossibletoachieve.Corey’scontributionshaveturnedtheartofsynthesisintoascience…NobelLectures:Chemistry1981-1990,WorldScientific,NewJersey,1992,pp677-708.E.G.Corey1928-TheNobelPrizeinChemistry2001ThesuccessofasymmetrichydrogenationlargelyusingBINAP-Rucomplexandits’extensiveusefulnessinindustry.RyojiNoyori1938-介绍一些有机合成方法学的大师TheNobelPrizeinChemistry2001

Thesuccessofasymmetricepoxidationandasymmetricdihydroxyaltionofthealkene.K.BarrySharpless1941-TheNobelPrizeinChemistry2005goestoYvesChauvin,RobertH.GrubbsandRichardR.Schrock"forthedevelopmentofthemetathesismethodinorganicsynthesis".OlefinMetathesis/GrubbsReaction:OlefinMetathesisallowstheexchangeofsubstituentsbetweendifferentolefins-atransalkylidenation.

CouplingReactionTheRoyalAcademyofSciencesannouncestheNobelPrizeinChemistry2010awardedjointlyto(portraitsseenonscreenfromleft)USA'sRichardF.Heck,JapaneseEi-ichiNegishiandAkiraSuzukiinStockholmonOctober6,2010.RichardHeckoftheUnitedStatesandJapan'sEi-ichiNegishiandAkiraSuzukisharedthe2010NobelChemistryPrizeWednesdayforpioneeringresearchinlinkingcarbonatoms.TheRoyalSwedishAcademyofScienceslaudedthetrio'sworkin"thedevelopmentofpalladium-catalyzedcrosscoupling."我所希望的教学模式课堂的教学学生课后的反馈Referencebook：《AdvancedOrganicChemistry》PartA:StrutureandMechanismsPartB:ReactionsandSynthesis

FrancisA.Carey&RichardJ.Sundberg高等有机化学-------反应与机理BernardMiller吴范宏译华东理工大学出版社现代有机反应(五卷)

胡跃飞林国强主编化学工业出版社1，有机反应的基本原理（2）2，取代基效应（5）3，取代、加成反应（8,9,11,12）4，消去反应（10）5，氧化还原反应（13）6，重排反应（15）7，周环反应（16）考核办法：平时成绩（10%）+作业（20%）+期末成绩（70%）Tellmewhathappenedifyouarenotavailable!!Makeagoodhomework!Thisisdefinitelyyouredge！第二章有机反应的基本原理一、反应的分类（1）按反应历程自由基反应：通过共价键的均裂而进行的反应。自由基反应一般在光或热的作用下进行。离子型反应：通过共价键的异裂而进行的反应。离子型反应一般在酸、碱等极性试剂的作用下进行。它又分为亲核反应和亲电反应。协同反应：旧键的断裂和新键的生成是同时进行的。（2）按原料和产物取代反应：卤代