Pim-1-2-kinase-inhibitor-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPim-1/2kinaseinhibitor1Cat.No.:HY-W412264CASNo.:6320-51-0分⼦式:C₁₁H₉NO₃S分⼦量:235.26作⽤靶点:Pim作⽤通路:JAK/STATSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(1062.65mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.2506mL21.2531mL42.5062mL5mM0.8501mL4.2506mL8.5012mL10mM0.4251mL2.1253mL4.2506mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Pim-1/2kinaseinhibitor1⼀种⼝服有效的Pim-1/2激酶抑制剂。Pim-1/2kinaseinhibitor1能阻断Pim激酶对肽的磷酸化能⼒，并且抑制4E-BP1和p27Kip1的Pim蛋⽩激酶定向磷酸化。Pim-1/2kinaseinhibitor1可⽤于癌症，尤其前列腺癌的研究。体外研究Pim-1/2kinaseinhibitor1(compoundD14)(varyingconcentrations;48h)showscytotoxicitytoPC3cells,1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEwithanICof11µM[1].CellCytotoxicityAssay[1]CellLine:PC3cellsConcentration:varyingconcentrationsIncubationTime:48hResult:InhibitedPC3cellswithanICof11µM.REFERENCES[1].CharlesD.Smith,etal.InhibitorsofPIM-1ProteinKinases,CompositionsandMethodsforTreatingProstateCancer.PatentUS20110263664A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0