FEMA-4774-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFEMA4774Cat.No.:HY-139091CASNo.:1359963-68-0分⼦式:C₁₉H₂₅N₃O₄分⼦量:359.42作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣FEMA4774物活性味觉受体T1R2和T1R3的正变构调节剂，其中T1R2和T1R3⼈类甜味受体的两个亚。FEMA4774也可作为蔗糖甜味增强剂体FEMA4774(0-50μM)inducesadose-dependentdecreaseintheEC50valueofsucroseandsignificantlyenhancestheaffinityofsucrosefo外研究体FEMA4774(S9632)(oralgavage,500-2000mg/kg)doesnotcauseadose-dependentincreaseinpolychromaticerythrocytesandinducesm内ThepharmacokineticparametersofFEMA4774(S9632)inMaleandFemaleSprague-DawleyRats研RouteDayDose(mg/kg)SexCmax(ng/mL)±SDTmax(hr)t1/2(hr)AUC0last(ng•hr/mL)AUC0last/dose(ng•hr/mL/mg/kg)%Fiv11.0M2036.7±281.究gavage110M12.9±117.9±2.31.790.54F34.0±749.2±7.84.921.1930M90.0±23.90.330.8890.8±11.03.030.92F62.4±25.90.4gavage710M16.2±3.60.500.8448.1±33.24.81-F32.7±9.70.331.1758.9±25.45.89-30M74.5±16.20.330.9486.0±8.72.87-F77.1±9106REFERENCES[1].GuyServant,etal.Thefunctionandallostericcontrolofthehumansweettastereceptor.AdvPharmacol.2020;88:59-82.[2].AmyJArthur,etal.Toxicologicalevaluationoftheflavouringredient4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid.ToxicolRep.2015Sep3;2:1255-1264.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>