RA375-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERA375Cat.No.:HY-136563分⼦式:C₃₀H₂₅ClN₄O₇分⼦量:589作⽤靶点:Proteasome;Apoptosis;ReactiveOxygenSpecies作⽤通路:MetabolicEnzyme/Protease;Apoptosis;Immunology/Inflammation;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:125mg/mL(212.22mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6978mL8.4890mL16.9779mL5mM0.3396mL1.6978mL3.3956mL10mM0.1698mL0.8489mL1.6978mLBIOLOGICALACTIVITY⽣物活性RA375RPN13(26S蛋⽩酶体亚)抑制剂。RA375激活UPR信号、ROS产⽣和凋亡。RA375的抗肿瘤活性10倍。体内研究RA375(10mg/kg,ip)inhibitsproteasomefunctionandreducesovariantumorburdeninmice[1].AnimalModel:RA375(10mg/kg,ip)inhibitsproteasomefunctionandreducesovariantumorburdeninmice[1].Dosage:10mg/kg.Administration:IPfora5dayson,2daysoffcyclefortwoweeks.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Reducedovariantumorburdeninmice.AnimalModel:FemaleBalb/cmice[1].Dosage:5,10,20,40,60,100mg/kg(PharmacologicalAnalysis).Administration:IPsingledose.Result:Thedoseof40mg/kgonalternatedaysfortwoweeksproducednoobservabletoxicitiesorweightloss.REFERENCES[1].RaviKAnchoori,etal.Structure-functionAnalysesofCandidateSmallMoleculeRPN13InhibitorsWithAntitumorProperties.PLoSOne.2020Jan15;15(1):e0227727.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792