ICP-MS(日立公司仪器)课件

ModelP-5000ICP-MSHitachiLtd.Instruments此文本为一会议报告，不属仪器分析课程要求的内容。有兴趣的同学可以看一看。ModelP-5000ICP-MSHitachiLtdICP/AESAtomicAbsorptionFurnacePlasma/MS(ICP/MS､MIP/MS)pptppb

ppmThrough-put(Elements/min)0.010.1110100SingleElementMultiElementAnalysis Analysis AtomicAbsorptionFlameP-5000P-4010Z-5010seriesP-6000AtomicAbsorptionFurnace&FlameICP-AESICP-MSMIP-MSLineUpforElementalAnalysis

SensitivityIontraptypeICP-MSHi-PowerMIP-MSICP/AESAtomicAbsorptionPlasmaICP-MS电感耦合等离子体质谱仪InductivelyCoupledPlasmaMassSpectrometryICP-MS等离子体-离子源质谱-按原子(分子)质量顺序排列的图谱质谱仪-质量分析仪,对带电粒子起作用,M/e与离子强度其他联用技术GC-MSHPLC-MS等离子体-离子源特点:无机质谱分析速度快线性范围宽可多元素测定80多种元素检出限低PPT特点:CharacteristicsP-5000的优势Combinationofaninductivelycoupledplasmaionsourceandaniontrapforelementalanalysis.1.Reductionofmatrixionsderivedfromargon

byusingtandemmassspectrometry(MS2)

2.Spacechargeeffectssuppressedbyusingfilterednoisefield(FNF)3.Ionconcentrationthroughtrapping(adetectionlimitispptlevelformostelements)CharacteristicsP-5000的优势Com要点:1.ICP和三维四极离子阱的结合是目前为止最佳的ICP-MS原因:MS2解决了分子离子的干扰FNF解决了空间电荷效应抑制问题离子阱的储存离子功能提高灵明度要点:IntroductionP-5000ICP-MSisthefirstiontraptypeICP-MSintheworld.Itoffers:1.LowBackgroundsignal2.Highsensitivity3.Widedynamicrange4.EasyoperationIntroductionP-5000ICP-MSistStructureofP-5000ICP-MSDetectorIontrapIonguideSamplingconeSkimmerconeTorchChamberNebulizerRotarypumpsTurbomolecularpumpsPeristalticpumpStructureofP-5000ICP-MSDeteComparisonofiontrapandconventionalQMS#Tandemmassspectrometry#Relativelycompactinstrument#Hightransmissionefficiencyintheselectedionmonitoring(SIM)modeQMS:transmittingtypeIontrap:trappingtypeWhatisIontrap?Comparisonofiontrapandcon提示:离子阱全能与ICP结合最佳四极杆适合选择离子检测与GC,LC配合更好提示:Iontrapbasicaction(Entrancegate)(Exitgate)IonsDetectorIonstrappingIondetectionTimeMultifunctionanalysisWhatisIontrap?open close closeclose close openEntrancegateExitgateIontrapbasicaction(Entrance1.Lowbackgroundsignal

InaP-5000system,collision-induceddissociationisusedtoeliminatetheinterferencefrommolecularions.

碰撞诱导分裂2.Hi-sensitivityandwidedynamicrange Bychangingtheiontrappingtime,itispossibletochangetheionsensitivity.阱的时间3.Easymeasurement

Simultaneousanalysis,qualitative,quantitativeanalysis.4.Ar-ICPionsource RF:27MHz,MaximumPower:1.4kWMainFeaturesofP-5000ICP-MS1.LowbackgroundsignalMainFMainproblemofconventionalICP-QMSMolecularionItisimpossibletodistinguishtheionswiththesamem/z.MeasurementionSamem/zSe+ArAr+Se+ArAr+ImpossibletodistinguishMainFeaturesofP-5000ICP-MSMainproblemofconventionalI:MeasurementIon :Moleculars :afterdissociationIntheP-5000system,next2stage 1.Naturaldecluster自然去簇 2.Collision-induceddissociation(CID)碰撞诱导分裂

isusedtoeliminatetheinterferencefrommolecularions.MainFeaturesofP-5000ICP-MS:MeasurementIon :MolecuEliminationmethodforthemolecularions.MainFeaturesofP-5000ICP-MSIontapCoolplasma+QMSReactioncell+QMSAr-molecularionsSensitivityofotherionsEliminationMetal-oxideionsPossiblePossiblePossiblePossibleImpossibleImpossibleGoodbadbadReactiongasHe-NH3,H2EliminationmethodforthemolDifferentofbackgroundspectrumMainFeaturesofP-5000ICP-MSICP-QMSP-5000IontrapICP-MSDifferentofbackgroundspectrBychangingtheiontrappingtime,possibletochangetheionsensitivity.

IntensityIontrappingtime110100100010000100001000100101

msecWidedynamicrangeMainFeaturesofP-5000ICP-MSBychangingtheiontrappingtCalibrationCurve1.000050100Concentration(ppt)208Pb400500600700Intensity

CalibrationCurve1.000050100

11BR2=1.00027AlR2=1.00055MnR2=1.00056FeR2=1.00063CuR2=1.00066ZnR2=1.00015000050100Conc.(ug/L)35000050100Conc.(ug/L)070000002550Conc.(ug/L)7000040000150300Conc.(ug/L)080000050100Conc.(ug/L)060000050100Conc.(ug/L)052CrR2=1.00060NiR2=1.00075AsR2=0.99802550Conc.(ug/L)3000020000510Conc.(ug/L)0600000510Conc.(ug/L)50000・0Analysisoftapwater11B27Al55Mn56Fe63Cu66Zn15080SeR2=0.99898MoR2=1.000112CdR2=1.000121SbR2=0.999208PbR2=1.000238UR2=0.9990510Conc.(ug/L)400000

04080Conc.(ug/L)250000510Conc.(ug/L)0

01.02.0Conc.(ug/L)60000500050000

02550Conc.(ug/L)50000001.02.0Conc.(ug/L)6000000Analysisoftapwater80Se98Mo112Cd121Sb208Pb238U40BackgroundSpectrum ----EfficiencyofiontrapICP-MS(1)---Purewater2%HNO32%HClBackgroundequivalentconcentrationofArOis5ppb(Fe).BackgroundSpectrumPurewaterAnalysisofFeatm/z=56 ----EfficiencyofiontrapICP-MS(2)---Calibrationcurveof56FeCalibrationcurveofµg/LrangecanbeobtainedforFeatm/z=56underthehotplasmacondition.IntensityFeconc.(µg/L)020406080100R2=0.999IntensityFeconc.(µg/L)0300060000510MeasurementforFeinthestandardsampleofriverwater(NISTSRM1643d)measured88.2elementFeQuantityofFeinNist1643d56Fe56Fe(Nist1643d)(µg/L)certified87.3-95.1AnalysisofFeatm/z=56CaliMeasurementforAsinthestandardsampleofriverwater(NISTSRM1643d)measured56.5elementFe(µg/L)certified55.29-56.75

750.3%NaCl75As(10ug/L)＋0.3%NaCl

Intensitym/zMassSpectrumofAsAnalysisofAs ----EfficiencyofiontrapICP-MS(3)---QuantityofAsinNist1643dR2=0.999Intensity0102030405060708090100Asconc.(ug/L)75As(Nist1643d)MeasurementforAsinthestan0200400600800100002000040000600008000010000012000014000016000018000080Se01020304050R2=0.99980SeConc.(µg/L)IntensityIntensity80SeConc.(ng/L)R2=0.999AnalysisofSeatm/z=80 ----EfficiencyofiontrapICP-MS(4)---Calibrationcurveofng/LrangecanbeobtainedforSeatm/z=80underthehotplasmacondition.MeasurementforSeinthestandardsampleofriverwater(NISTSRM1643d)measured11.6elementFeQuantityofSeinNist1643d(µg/L)certified11.26-11.60Calibrationcurveof80Se80Se(Nist1643d)020040060080010000200004000060Measurementof80Se(ng/L)byusingCID ----EfficiencyofiontrapICP-MS(5)---

02040608010001000020000300004000050000Highlybackground

Concentration(ng/l)Count(arb.unit)020406080100010002000300040005000

Count(arb.unit)R2=0.998Concentration(ng/l)CIDoffCIDonEliminate80Se80SeMeasurementof80Se(ng/L)by

#Interferenceofmetal-oxideion(eg.CaO＋)canbedecreased.#56FecanbemeasuredincludingthehighmatrixofCa.CIDon30ppmCa+1ppbFeCIDon30ppmCaCIDoff30ppmCam/z55.556.056.50DecreasingbyCIDCoolplasmaorcollisioncellcannotdecreasetheinterferenceofCaOMeasurementof56FeinCabyusingCID ----EfficiencyofiontrapICP-MS(6)---Intensity(arb.unit)#Interferenceofmetal-oxideSimultaneousMeasurementfortheSamplewithVarietyConcentration ----EfficiencyofiontrapICP-MS(7)---Thesampleincludingtheelementswithovermg/Lconcentrationandunderµg/Lconcentrationcanbemeasuredsimultaneouslybychangingtheiontrappingtime.

02040608010001000023Na

r2=0.9993IntensityConc.(mg/L)0.00.51.01.52.0012000238U2r=0.9993IntensityConc.(µg/L)Calibrationcurveofµg/LrangeofUCalibrationcurveofmg/LrangeofUSimultaneousMeasurementfortSpecificationsICPionsource Radiofrequency :27.12MHz Power :0.7-1.4kW FullycomputercontrolledsolidstateRFgenerator Stage :X-Y-ZautomaticadjustableSampleintroduction Torch :FasselType Chamber :ScottType(Option:cooled) Nebulizer :Concentricnebulizer PeristalticpumpVacuumSystem 3stagevacuum Interfacevacuum :Rotarypump Ionlenschamber :Turbopump Analyzerchamber :TurbopumpAnalyzer Iontraptype :Compacttype MS-MSfunction :tandemmassspectrometry(MS2)

SpecificationsICPionsourceSpecificationsIondetection ElectronmultiplierMassrange 5-300amuDetectionlimit :pptlevelformostelementsLineardynamicrange :8ordersSizeandweight

Height :810mm Width :1180mm Depth :710mm Weight :300kg

SpecificationsIondetection几种附件:自动进样器超声波雾化器氢化物发生器氢氟酸进样系统几种附件:应用(I)*生物和医学金属蛋白络合物人血清中的难溶元素血浆中的Mo植物中的Pt尿样中的无机Se和有机Se应用(I)应用(II)*环境与食品气溶胶大气中的微粒物质海水中的微量金属极地冰雪中的铁环境荷尔蒙PbCdHg酒中生物配合物中的Pb

应用(II)应用(III)*地质钢铁稀土材料贵金属高纯物质分析陶瓷长石锆石矿石中的液体包容物同位素比应用(III)销售目标:*科研主要市场环境!*检测贵金属地矿稀土材料经典市场!销售目标:说法:强调MS部分1.ICP与离子阱是最好的联用方式,离子阱MS2和储存离子提高灵敏度2.分子离子干扰处理的很好,空间电荷效应抑制得到解决,这是其他常规ICP-MS做不到3.碰撞诱导分裂-独特!MS2的功能4.目前只有日立有ICP与离子阱联用仪器5.液相色谱附件6.体积小巧说法:强调MS部分ModelP-5000ICP-MSHitachiLtd.Instruments此文本为一会议报告，不属仪器分析课程要求的内容。有兴趣的同学可以看一看。ModelP-5000ICP-MSHitachiLtdICP/AESAtomicAbsorptionFurnacePlasma/MS(ICP/MS､MIP/MS)pptppb

ppmThrough-put(Elements/min)0.010.1110100SingleElementMultiElementAnalysis Analysis AtomicAbsorptionFlameP-5000P-4010Z-5010seriesP-6000AtomicAbsorptionFurnace&FlameICP-AESICP-MSMIP-MSLineUpforElementalAnalysis

SensitivityIontraptypeICP-MSHi-PowerMIP-MSICP/AESAtomicAbsorptionPlasmaICP-MS电感耦合等离子体质谱仪InductivelyCoupledPlasmaMassSpectrometryICP-MS等离子体-离子源质谱-按原子(分子)质量顺序排列的图谱质谱仪-质量分析仪,对带电粒子起作用,M/e与离子强度其他联用技术GC-MSHPLC-MS等离子体-离子源特点:无机质谱分析速度快线性范围宽可多元素测定80多种元素检出限低PPT特点:CharacteristicsP-5000的优势Combinationofaninductivelycoupledplasmaionsourceandaniontrapforelementalanalysis.1.Reductionofmatrixionsderivedfromargon

byusingtandemmassspectrometry(MS2)

2.Spacechargeeffectssuppressedbyusingfilterednoisefield(FNF)3.Ionconcentrationthroughtrapping(adetectionlimitispptlevelformostelements)CharacteristicsP-5000的优势Com要点:1.ICP和三维四极离子阱的结合是目前为止最佳的ICP-MS原因:MS2解决了分子离子的干扰FNF解决了空间电荷效应抑制问题离子阱的储存离子功能提高灵明度要点:IntroductionP-5000ICP-MSisthefirstiontraptypeICP-MSintheworld.Itoffers:1.LowBackgroundsignal2.Highsensitivity3.Widedynamicrange4.EasyoperationIntroductionP-5000ICP-MSistStructureofP-5000ICP-MSDetectorIontrapIonguideSamplingconeSkimmerconeTorchChamberNebulizerRotarypumpsTurbomolecularpumpsPeristalticpumpStructureofP-5000ICP-MSDeteComparisonofiontrapandconventionalQMS#Tandemmassspectrometry#Relativelycompactinstrument#Hightransmissionefficiencyintheselectedionmonitoring(SIM)modeQMS:transmittingtypeIontrap:trappingtypeWhatisIontrap?Comparisonofiontrapandcon提示:离子阱全能与ICP结合最佳四极杆适合选择离子检测与GC,LC配合更好提示:Iontrapbasicaction(Entrancegate)(Exitgate)IonsDetectorIonstrappingIondetectionTimeMultifunctionanalysisWhatisIontrap?open close closeclose close openEntrancegateExitgateIontrapbasicaction(Entrance1.Lowbackgroundsignal

InaP-5000system,collision-induceddissociationisusedtoeliminatetheinterferencefrommolecularions.

碰撞诱导分裂2.Hi-sensitivityandwidedynamicrange Bychangingtheiontrappingtime,itispossibletochangetheionsensitivity.阱的时间3.Easymeasurement

Simultaneousanalysis,qualitative,quantitativeanalysis.4.Ar-ICPionsource RF:27MHz,MaximumPower:1.4kWMainFeaturesofP-5000ICP-MS1.LowbackgroundsignalMainFMainproblemofconventionalICP-QMSMolecularionItisimpossibletodistinguishtheionswiththesamem/z.MeasurementionSamem/zSe+ArAr+Se+ArAr+ImpossibletodistinguishMainFeaturesofP-5000ICP-MSMainproblemofconventionalI:MeasurementIon :Moleculars :afterdissociationIntheP-5000system,next2stage 1.Naturaldecluster自然去簇 2.Collision-induceddissociation(CID)碰撞诱导分裂

isusedtoeliminatetheinterferencefrommolecularions.MainFeaturesofP-5000ICP-MS:MeasurementIon :MolecuEliminationmethodforthemolecularions.MainFeaturesofP-5000ICP-MSIontapCoolplasma+QMSReactioncell+QMSAr-molecularionsSensitivityofotherionsEliminationMetal-oxideionsPossiblePossiblePossiblePossibleImpossibleImpossibleGoodbadbadReactiongasHe-NH3,H2EliminationmethodforthemolDifferentofbackgroundspectrumMainFeaturesofP-5000ICP-MSICP-QMSP-5000IontrapICP-MSDifferentofbackgroundspectrBychangingtheiontrappingtime,possibletochangetheionsensitivity.

IntensityIontrappingtime110100100010000100001000100101

msecWidedynamicrangeMainFeaturesofP-5000ICP-MSBychangingtheiontrappingtCalibrationCurve1.000050100Concentration(ppt)208Pb400500600700Intensity

CalibrationCurve1.000050100

11BR2=1.00027AlR2=1.00055MnR2=1.00056FeR2=1.00063CuR2=1.00066ZnR2=1.00015000050100Conc.(ug/L)35000050100Conc.(ug/L)070000002550Conc.(ug/L)7000040000150300Conc.(ug/L)080000050100Conc.(ug/L)060000050100Conc.(ug/L)052CrR2=1.00060NiR2=1.00075AsR2=0.99802550Conc.(ug/L)3000020000510Conc.(ug/L)0600000510Conc.(ug/L)50000・0Analysisoftapwater11B27Al55Mn56Fe63Cu66Zn15080SeR2=0.99898MoR2=1.000112CdR2=1.000121SbR2=0.999208PbR2=1.000238UR2=0.9990510Conc.(ug/L)400000

04080Conc.(ug/L)250000510Conc.(ug/L)0

01.02.0Conc.(ug/L)60000500050000

02550Conc.(ug/L)50000001.02.0Conc.(ug/L)6000000Analysisoftapwater80Se98Mo112Cd121Sb208Pb238U40BackgroundSpectrum ----EfficiencyofiontrapICP-MS(1)---Purewater2%HNO32%HClBackgroundequivalentconcentrationofArOis5ppb(Fe).BackgroundSpectrumPurewaterAnalysisofFeatm/z=56 ----EfficiencyofiontrapICP-MS(2)---Calibrationcurveof56FeCalibrationcurveofµg/LrangecanbeobtainedforFeatm/z=56underthehotplasmacondition.IntensityFeconc.(µg/L)020406080100R2=0.999IntensityFeconc.(µg/L)0300060000510MeasurementforFeinthestandardsampleofriverwater(NISTSRM1643d)measured88.2elementFeQuantityofFeinNist1643d56Fe56Fe(Nist1643d)(µg/L)certified87.3-95.1AnalysisofFeatm/z=56CaliMeasurementforAsinthestandardsampleofriverwater(NISTSRM1643d)measured56.5elementFe(µg/L)certified55.29-56.75

750.3%NaCl75As(10ug/L)＋0.3%NaCl

Intensitym/zMassSpectrumofAsAnalysisofAs ----EfficiencyofiontrapICP-MS(3)---QuantityofAsinNist1643dR2=0.999Intensity0102030405060708090100Asconc.(ug/L)75As(Nist1643d)MeasurementforAsinthestan0200400600800100002000040000600008000010000012000014000016000018000080Se01020304050R2=0.99980SeConc.(µg/L)IntensityIntensity80SeConc.(ng/L)R2=0.999AnalysisofSeatm/z=80 ----EfficiencyofiontrapICP-MS(4)---Calibrationcurveofng/LrangecanbeobtainedforSeatm/z=80underthehotplasmacondition.MeasurementforSeinthestandardsampleofriverwater(NISTSRM1643d)measured11.6elementFeQuantityofSeinNist1643d(µg/L)certified11.26-11.60Calibrationcurveof80Se80Se(Nist1643d)020040060080010000200004000060Measurementof80Se(ng/L)byusingCID ----EfficiencyofiontrapICP-MS(5)---

02040608010001000020000300004000050000Highlybackground

Concentration(ng/l)Count(arb.unit)020406080100010002000300040005000

Count(arb.unit)R2=0.998Concentration(ng/l)CIDoffCIDonEliminate80Se80SeMeasurementof80Se(ng/L)by

#Interferenceofmetal-oxideion(eg.CaO＋)canbedecreased.#56FecanbemeasuredincludingthehighmatrixofCa.CIDon30ppmCa+1ppbFeCIDon30ppmCaCIDoff30ppmCam/z55.556.056.50DecreasingbyCIDC