SQ609-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESQ609Cat.No.:HY-139424CASNo.:627052-25-9分⼦式:C₂₂H₃₈N₂O分⼦量:346.55作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:6.67mg/mL(19.25mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8856mL14.4279mL28.8559mL5mM0.5771mL2.8856mL5.7712mL10mM0.2886mL1.4428mL2.8856mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥0.67mg/mL(1.93mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥0.67mg/mL(1.93mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性SQ609⼀种来⾃⼆哌啶库的先导化合物。SQ609在4μg/ml时抑制90%以上的细胞内细⽣长，并且对这些细胞有毒。SQ609显⽰出强⼤的抗结核活性[1]。体外研究InMtb-infectedmacrophagesinvitro,SQ609inhibitsmorethan90%ofintracellularbacterialgrowthat4μg/mlandistoxictothesecells[1].体内研究SQ609(10mg/kg;intravenousinjection)completelypreventsweightlossintheMtb-infectedanimalsandprolongsthetherapeuticeffectfollowingdrugwithdrawalforanother10-15days[1].AnimalModel:TBsusceptiblemice(C3H/He)[1]Dosage:10mg/kgAdministration:I.v.Result:PreventedweightlossintheMtb-infectedanimalsandprolongedthetherapeuticeffectfollowingdrugwithdrawalforanother10-15days.REFERENCES[1].BogatchevaE,etal.IdentificationofSQ609asaleadcompoundfromalibraryofdipiperidines.BioorgMedChemLett.2011;21(18):5353-5357.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82