SBC-115337-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESBC-115337Cat.No.:HY-141714CASNo.:423148-46-3分⼦式:C₂₉H₁₉N₃O₄分⼦量:473.48作⽤靶点:Ser/ThrProtease作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:6.67mg/mL(14.09mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1120mL10.5601mL21.1202mL5mM0.4224mL2.1120mL4.2240mL10mM0.2112mL1.0560mL2.1120mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性SBC-115337⼀种有效的苯并呋喃化合物，PCSK9抑制剂，IC50值为0.5μM[1][2]。IC50&TargetIC50:0.5μM(PCSK9)[1]体外研究Thepotentcompound(SBC-115,337)showsanIC50of0.6μMmeasuredinaninvitroELISAassayto1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEmonitortheeffectofPCSK9bindingtotherecombinantLDLR.SBC-115,337at1.2μMinducesmorethantenfoldupregulationofLDLRinHepG2cellswithrespecttothecontrol,increasesuptakeoffluorescentlylabeledDiI-LDLandloweresLDL-clevelsinmicefedahigh-fatdiet[2].REFERENCES[1].XuS,etal.SmallmoleculesasinhibitorsofPCSK9:Currentstatusandfuturechallenges.EurJMedChem.2019;162:212-233.[2].LavecchiaA,etal.RecentadvancesindevelopingPCSK9inhibitorsforlipid-loweringtherapy.FutureMedChem.2019;11(5):423-441.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>