Gadolinium-chloride-GdCl3-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGadoliniumchlorideCat.No.:HY-103314CASNo.:10138-52-0Synonyms:GdCl3分⼦式:Cl₃Gd分⼦量:263.61作⽤靶点:CaSR作⽤通路:GPCR/GProtein储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验1MHCl:100mg/mL(379.35mM;ultrasonicandadjustpHto1withHCl)DMSO:<1mg/mL(ultrasonic;warming;heatto60°C)(insolubleorslightlysoluble)H2O:<0.1mg/mL(ultrasonic;warming;heatto60°C)(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.7935mL18.9674mL37.9348mL5mM0.7587mL3.7935mL7.5870mL10mM0.3793mL1.8967mL3.7935mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Gadoliniumchloride⼀种特殊的钙敏感受体(CaSR)激动剂。Gadoliniumchloride可⽤于⼼⾎管疾病的研究1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1]。IC50&TargetCaSR[1]体外研究Gadoliniumchloride(30μM;15minutes;H9c2cells)resultsinincreasedBaxexpressionandcaspase-3activation,anddecreasedBcl-2expressioninCsA-inducedcells[1].Invitro,GdCl3,aCaSRagonist,hasbeenshowntopromotetheapoptosisofmyocardialcells,whichincreasesERK1/2phosphorylationandactivatescaspase-3[1].WesternBlotAnalysis[1]CellLine:H9c2cellsConcentration:30μMIncubationTime:15minutesResult:ResultedinincreasedBaxexpressionandcaspase-3activation,anddecreasedBcl-2expressioninCsA-inducedcells.REFERENCES[1].LiX,etal.CalciumOxalateInducesRenalInjurythroughCalcium-SensingReceptor.OxidMedCellLongev.2016;2016:5203801.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-