Amoscanate-CGP4540-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAmoscanateCat.No.:HY-129051CASNo.:26328-53-0Synonyms:CGP4540分⼦式:C₁₃H₉N₃O₂S分⼦量:271.29作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:50mg/mL(184.30mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.6861mL18.4305mL36.8609mL5mM0.7372mL3.6861mL7.3722mL10mM0.3686mL1.8430mL3.6861mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Amoscanate(CGP4540)苯异硫氰酸酯，其中对位的氢被⼀个4-硝苯胺取代。Amoscanate⼀种抗⾎吸⾍药。Amoscanate作为⼀种异硫氰酸酯化合物和氧化磷酸化解耦剂，对⿏室管膜有明显的损伤作⽤[1]。体内研究Amoscanate(500mg/kg;p.o.;10days)destructsependymaandperiventricularbrain[1].Amoscanate(250and500mg/kg;p.o.;28days)elicitsnecrosis,Ca++-positivemicrogranules,pyknosisand1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEedemalocalizedinependyma/subependymainthemedialstriatum[1].Amoscanate(25~500mg/kg;p.o.;20days)elicitsprogressivenecrosisofependyma[1].Amoscanateelicitsmassiveultrastructuraldamageinependymalcells[1].AnimalModel:Sprague-Dawleyrats[1]Dosage:500mg/kgAdministration:P.o.;10daysResult:Destructedependymaandperiventricularbrain.AnimalModel:Sprague-Dawleyrats[1]Dosage:250and500mg/kgAdministration:P.o.;28daysResult:Elicitednecrosis,Ca++-positivemicrogranules,pyknosisandedemalocalizedinependyma/subependymainthemedialstriatum.AnimalModel:Sprague-Dawleyrats[1]Dosage:25~500mg/kgAdministration:P.o.;20daysResult:Elicitedprogressivenecrosisofependymal.REFERENCES[1].JohansonC,etal.Thedistributionalnexusofchoroidplexustocerebrospinalfluid,ependymaandbrain:toxicologic/pathologicphenomena,periventriculardestabilization,andlesionspread.ToxicolPathol.2011;39(1):186-212.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te