SNDX-5613-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemESNDX-5613Cat.No.:HY-136175CASNo.:2169919-21-3分⼦式:C₃₂H₄₇FN₆O₄S分⼦量:630.82作⽤靶点:EpigeneticReaderDomain作⽤通路:Epigenetics储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:41.67mg/mL(66.06mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.5852mL7.9262mL15.8524mL5mM0.3170mL1.5852mL3.1705mL10mM0.1585mL0.7926mL1.5852mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥4.17mg/mL(6.61mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥4.17mg/mL(6.61mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥4.17mg/mL(6.61mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性SNDX-5613⼀种有效的特异性Menin-MLL抑制剂，结合Ki为0.149nM，细胞实验中，抑制Menin-MLL的IC50为10-20nM[1]。SNDX-5613可⽤于MLL因重排的急性⽩⾎病研究，包括急性淋巴细胞⽩⾎病(ALL)和急性髓细胞⽩⾎病(AML)[1]。IC50&TargetMenin-MLL[1]体内研究SNDX-5613showsinvivoplasmaIC50of53nM.SNDX-5613treatmentprovidessignificantsurvivalbenefitandleukemiccontrolinaggressiveMOLM-13disseminatedxenografts[1].REFERENCES[1].Adrug,SNDX-5613,totreatacuteleukemiawithaKMT2AtranslocationoranNPM1mutationthathascomeback(relapsed)orhasnotgottenbetterwithtreatment(refractory).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021