小儿缺铁性贫血采用蛋白琥珀酸铁治疗效果观察

小儿缺铁性贫血采用蛋白琥珀酸铁治疗效果观察/r/n将结果回顾如下。/r/n资料与方法/r/n一般资料/r/n100/r/n2021/r/n5/r/n-2021/r/n5/r/n7/r/n50/r/n23/r/n27/r/n0/r/n3/r/n岁，平均/r/n1.4±0/r/n3/r/n岁，病程平均/r/n3.2±0/r/n5/r/n个月；轻度/r/n47/r/n2/r/n1/r/n50/r/n24/r/n26/r/n0/r/n～3/r/n岁，平均/r/n1.5±0/r/n2/r/n岁，病程平均/r/n3.5±0/r/n3/r/n个月；轻度/r/n46/r/n例，中度/r/n3/r/n1/r/nP0.0/r/n。/r/n方法/r/n观察组：本组患儿给予蛋白琥珀酸铁（菲普利，生产厂家：意大/r/nH***-***/r/n*/r/n为/r/n1.5/r/n/r/nm/r/n//r/nkg/r/n，分/r/n2/r/n次于餐前服用，以/r/n7/r/n周为/r/n1/r/n疗程。对照组：/r/n本组给予硫酸♘铁糖浆（生产企业：内蒙古惠丰药业有限公司，批准/r/n

/r/n1.5/r/n/r/n

/r/n分/r/n2/r/n7周为1疗程。两组用药期间，均告知家长应让患儿多食富含维生素/r/n及铁元素的食物。/r/n观察指标/r/n（1）/r/n微量元素检测：以原子吸收光谱法，应用全自动原子吸收分光光度计（AAS-5000/r/n型/r/n）对用药前后患儿微量元素镉、锌、钙、/r/n（2）/r/n血液学指标：以光电比色法，应用AU5800/r/n全自动生化仪对用药前后患儿血红蛋白（Hb/r/n、红细胞（RBC/r/n）/r/n（3）/r/n铁代谢指标：以固相放射免疫法，应用/r/nAu5800/r/n全自动生化仪对用药前后患儿血清铁/r/n和血清铁蛋白/r/n进行检测；并应用免疫散射比浊法对用药前后患儿总铁结合力（TRBF/r/n）和血清转铁蛋白/r/n（4）/r/n记录用药期间不良反应情况。随访6/r/n效果评定/r/n显效：贫血症状消失，血液学指标正常；有效：贫血症状改善，血液学指标相对恢复；无效：贫血症状改善不明显，血液学指标无变化。总有效=显效+有效。/r/n统计学处理/r/n涉及数据均输入/r/nSPSS/r/n/r/n19./r/n，组间计量采用/r/nx±/r/n）表示，行/r/nt/r/n检/r/n验，计数资料以率/r/n表示，行字/r/n2/r/n义。/r/n结果/r/n微量元素比较/r/n计学意义/r/nP0.0/r/n，用药后，镉均有下降，锌、铜、铁均有升高，但观察组下降和升高幅度较对照组更为显著/r/nP0.0/r/n，见表/r/n1/r/n。/r/n血清学指标/r/nHb/r/nRBC/r/n用药后均有升高，观察组幅度较对照组更为明显/r/nP0.0/r/n，见表/r/n2/r/n。/r/n铁代谢指标/r/nTRBF/r/nS/r/nT/r/nS/r/nP0.0/r/n，/r/nTRBF/r/nTF/r/n、SF/r/n组上述指标下降和升高幅度更为明显/r/nP0.0/r/n，见表/r/n3/r/n。/r/n临床效果/r/n98/r/n84%，/r/n差异有统计学意义/r/nP0.0/r/n，见表/r/n4/r/n。/r/n不良反应率及复发率对比/r/n1/r/n2/r/n1/r/n3/r/n4/r/n16%，组间对比差异有统计学意义/r/nP0.0/r/n。随访/r/n6/r/n1/r/n2/r/n7/r/n14/r/nP0