MS31-trihydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMS31 trihydrochlorideCat. No.: HY-125837A分式: CHClNO分量: 450.83作靶点: Epigenetic Reader Domain作通路: Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (138.63 mM; Need ultraso

2、nic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2181 mL 11.0907 mL 22.1813 mL5 mM 0.4436 mL 2.2181 mL 4.4363 mL10 mM 0.2218 mL 1.1091 mL 2.2181 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 MS31 trihydrochloride种亲和性和选择性的，段样的甲赖氨酸读写蛋 spindlin 1 (SPIN1) 抑制剂，有效破坏 SPIN1 与

3、H3K4me3 蛋互相作 (IC50=77 nM，AlphaLISA；243 nM，FP). MS31trihydrochloride 选择性结合 SPIN1 的 Tudor 结构域 II (Kd=91 nM)。MS31 trihydrochloride 能有效抑制含三甲赖氨酸肽与 SPIN1 的结合，对肿瘤性细胞毒 1。IC50 & Target IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP) 1Kd: 91 nM (SPIN1) 11/2 Master of Small Molecules 您边的抑制剂师www.MedChemE

4、体外研究 MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays highbinding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engagesSPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 trihydrochlorid

5、e selectively binds tudor domainII of SPIN1 1.REFERENCES1. Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J MedChem. 2019 Jul 24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589