skin中文dg中5念珠菌病

1、DavidGrant AetiologyAetiologyCandidaspp.,especiallyC.normalinhabitant(commensalendo-saprophyte)ofthe alimentary, upper respiratory and ano-genital mucosaround to oval yeast organism which is able to produce a myceliumandchlamydosporesinculture圆形至椭圆酵母producesacidproteinases,keratinasesand phospholipa

2、ses (virulence factors)PathogenesisofprolongeduseofPathogenesisofprolongeduseofdrugscorticosteroids,immunosuppressivesantibiotics(esp.broad-抗生素（特别是广谱抗生素ingdiseases,disruptionofcutaneous/mucosal皮肤/Burns persistentmoisture,macerationindwellingcathetersClinicalfeatures临床特rareinfectioninClinicalfeatures

3、临床特rareinfectioninsmallanimals morefrequently reported in罕mucousmembranesandhumid/softened粘膜和潮湿/cutaneous softensecondaryto(oral, vaginal) 皮肤病变经常继发于粘膜（）Clinicalpicture临床表whiteopaquefilmorcoat,milky/cheesyClinicalpicture临床表whiteopaquefilmorcoat,milky/cheesy白色不透明的薄，奶油色/skin and mucosa are erythematous

4、 and ulcerated ie皮肤和粘膜发红和溃疡深度侵入组hemouth:whiteplaquesandulcerationofthemucous lining of the cheeks and ventral tongue and foul-smelling otitisexterna,paronychia,pruritusmay炎CourtesyCourtesyDidierDifferentialdiagnosispyoderma,acutemoistothercausesDifferentialdiagnosispyoderma,acutemoistothercausesofot

5、itisertrigo(foldpyoderma擦疹ulcerativeautoimmunediseases junctional diseases, LE)性皮炎drugeruptions,NMEhepatocutaneoussyndrome坏死移行红斑-MF theliotropiclymphoma蕈样肉芽肿-leishmaniasis,Cytologyofdirectsmear直接涂片的细胞Cytologyofdirectsmear直接涂片的细胞学检stainwithlactophenolcottonbluedegeneratedneutrophilsnumerousroundtoova

6、lyeasts(2-大量圆形至椭圆形的酵母菌(2-子芽细胞(budding （ narrow-basemultilateral alCourtesyCourtesyDidierBiopsy(H&E or活检(H&Eordermitis,allyBiopsy(H&E or活检(H&Eordermitis,allysuppurativeyeastsandhestratum ,al(pseudo) 酵母菌和芽生孢子存在于角质层，偶见（假）Diagnosis诊Diagnosis诊Fungalculture(25-30C,24-真菌培养(25-30C,24-Sabourauddextroseagaris

7、olationofafewcoloniesfromsalivaorfaeceshasno pathological significancetruecandidainfectiononlyifyeastispresentinlarge numbers and if mycelium is detected in vivoAPIsystemtoidentifycandidaspecies API 系统鉴定念珠菌种类J. van Cutsem, F. Rochette:MycosesJ. van Cutsem, F. Rochette:Mycosesin Domestic Animals, Janssen Research Foundation 1991TreatmentCorrectionTreatmentCorrectionofpredisposingTopicalagentsmi