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1、CHAPTER1INTRODUCTIONSummaryPhysiologyisthestudyofhowlivingorganismswork.Itisthesciencethatdescribethenormalfunctionsandtheirregularpatternsofthelivingorganisms.Thevastfieldofphysiologycanbedividedintoviralphysiology,bacterialphysiology,cellularphysiology,plantphysiology,humanphysiology,andmanymoresu
2、bdivisions.However,theHumanPhysiologyisveryimportantandbasicbiomedicalcourseformedicalstudents.Thebodyhasthreefundamentalcharacteristicsoflivingorganismwhicharemetabolism,excitabilityandreproduction.Themetabolismincludematerialmetabolismandenergymetabolism.Thematerialmetabolismsofcarbonhydrate,lipid
3、,proteinsetc.havemainlybeenlearnedinBIOCHMISTRY.Theenergymetabolismwillbelearnedinthe7thChapterinPHYSIOLOGY.Theexcitabilityisveryimportantphysiologicalterm,thepropertyoflivingorganismsthatpermitthemtoreacttostimuliisdefinedasexcitability.Sincethenormalfunctionsoforgansororgansystemswasemphasized,hom
4、eostasisisanotherveryimportantphysiologicalconcept.Homeostasissignifiesastableandconstantstatusoftheinternalenviromentinthebodyoflivingorganism.ItisadynamicbalanceofpH,osmosticpressure,temperature,ionsconcentrations,andsoon.Homeostasisisanecessaryforthenormalfunctionsofcells,organsandorgansystems.Th
5、erefore,homeostasisisthesoulconceptofPHYSIOLOGY.Thelivingorganismneedstoovercomethepossibledisordercausedbythemetabolisms,thenhomeostasiscouldbemaintainedandthenormalfunctionsofthelivingorganismscouldbegoneon.Howtomaintainthehomeostasis?Therearemainlythreemechanismstomaintainthehomeostasis.Theyarene
6、uralregulation,humoralregulationandauto-regulation.Threeregulatorypatternsexhibitdifferentmechanismsandfeatures.Feedback,atermborrowedfromengineering,isafundamentalfeatureofhomeostasis.Feedbackregulationanticipateschangesinaregulatedvariable,improvesthespeedofthebodyshomeostaticresponses,andminimize
7、sfluctuationsinthelevelofthevariablebeingregulated.Inthenegativefeedbacksystem,achangeinthevariablebeingregulatedbringsaboutresponsethattendtopushthevariableinthedirectionoppositetotheoriginalchange.Thehomeostasiscouldbemaintainedafternegativefeedbackregulation.Inpositivefeedbacksystem,aninitialdist
8、urbanceinthesystemsetsoffatrainofeventsthatincreasesthedisturbanceevenfurther.Somespecialphysiologicalactivitiesinthelivingorganismarecarriedoutbythepositivefeedbacksystemsuchasprocessesofgivingbirth,bloodcoagulation,micturition.DefinitionPhysiology(生理学)Acuteexperiment(急性实验)Chronicexperiments(慢性实验)I
9、nvitro(离体)Invivo(在体)Metabolism(新陈代谢)Interstitialfluid(组织间液)Internalenvironment(内环境)Homeostasis(稳态)Excitability(兴奋性)Excitation(兴奋)Inhibition(抑制)Stimulus(刺激)Neuralregulation(神经调节)Neuro-humoralregulation(神经体液调节)Reflexarc(反射弧)Unconditionedreflex(非条件反射)Conditionedreflex(条件反射)Humoralregulation(体液调节)Auto-r
10、egulation(自身调节)Feedback(反馈)Negativefeedback(负反馈)Positivefeedback(正反馈)Feedforward(前馈)ChoosetheONEbestanswer,thenfillthecorrespondingletterintheblank.(C)1.Whichoneofthefollowingisaphysiologicalprocesswithnegativefeedback?BloodcoagulationProcessofpassingurineSino-aorticbaroreceptorreflexNa+influxduring
11、actionpotentialProcessofparturition(D)2.Whichoneofthefollowingisnotthepropertyofregulationbyhormone?SlowinonsetDiffuseinnatureLongerindurationAccurateinactionActioninovercorrection(D)3.Whichofthefollowingisnotthefundamentalcharacteristicoflivingorganisms?MetabolismExcitabilityReproductionPassivediff
12、usionAdaption(D)4.Theconceptofhomeostasisincludestheconceptofanerrorsignal.referstomaintainingphysiologicalfunctionsinastablecondition.refersonlytotheregulationofbodytemperature.AandBBandC(A)5.ThistermreferstotheexistenceofastableinternalenvironmentHomeostasisFeedbackAutoregulationAlltheaboveNoneoft
13、heabove(C)6.Whichoneofthefollowingprovideslong-termregulatorycontrolthatresultsinrelativelyunchanginginternalconditions.PositiveFeedbackDiseaseNegativeFeedbackAlltheaboveNoneoftheabove(B)7.MovingyourhandawayfromahotstoveisanexampleofabasicfunctioncalledPositivefeedbackResponseRegulationAlltheaboveNo
14、neoftheabove(E)8.OntheobjectsthatPhysiologyresearchesandobserves,whichofthefollowingiscorrectdescription?WholebodylevelOrganandorgansystemslevelsCellularlevelMolecularlevelAlltheabove(E)9.OnthemethodologyappliedinPhysiology,whichofthefollowingiscorrect?AcuteexperimentChronicexperimentExperimentinviv
15、oExperimentinvitroE.Alltheabove(D)10.Theaccelerationofheartbeatcausedbycatecholaminehormonesreleasedfromadrenalglandafterdoingexercise,itisNeuralregulationHumoralregulationAutoregulationNeural-humoralregulationNoneoftheaboveQuestions:Whatarethefivecomponentsofthereflexarc?Whatarefundamentalcharacter
16、isticsoflivingorganism?Explainthemechanismsofhowtomaintainthehomeostasisinlivingorganism.Contrastthepropertiesoftheneuralregulation,humoralregulationandauto-regulation.Describethecategoryofthehumoralregulation.Answers:Definitions:Physiology(生理学):Physiologyisthestudyofhowlivingorganismswork,thegoalof
17、physiologyistostudythenormalfunctionsandtheirregularpatternsoforgansororgansystemsoflivingorganism.Acuteexperiment(急性实验):Experimentperformedistostudythephysiologicalactivitiesortoobservethereactiontotheexternalinterferenceinshorttimeiscalledacuteexperiment.Theanimalsusedareoftenlyunderanesthesia,and
18、theexperimentsareoftenlydestructiveandirreversible,eveninducethedeathofanimals.Theacuteexperimentincludeexperimentinvivoandinvitro.Chronicexperiments(慢性实验):Experimentperformedistostudythephysiologicalactivitiesortoobservethereactiontotheexternalinterferenceinlongtimeiscalledchronicexperiment.TheChro
19、nicexperimentsmaybeperformedonconscioussubjectforalongperiodoftimeafterrecoveryfromtheoperation.Invitro(离体):Experimentisperformedonanisolatedtissueororganthatistakenoutfromthebodyoftheanimal.Invivo(在体):Experimentisperformedonthewholebodyoftheanimaltoobserveoneorsomephysiologicalfunctionsoftheorganor
20、organsystems.Metabolism(新陈代谢):Metabolismistheoneofbasiccharacteristicsoflivingorganism.Itmeansallthechemicalreactionsinallthecellsofthebody,andincludesallmaterialandenergytransformationsthatoccurinthebody.Thematerialmetabolismincludescatabolicandanabolicreactions.Interstitialfluid(组织间液):Thespacesbet
21、weencellsarecalledtheinterstitutium,thefluidinthesespacesistheinterstitialfluid.Internalenvironment(内环境):Itistheenvironmentthatallcellsofthebodyliveintheextracellularfluid,whichiscalledtheinternalenvironmentofthebody.Homeostasis(稳态):Thestatemaintenanceofaconstancyandbalanceinonesinternalenvironment.
22、Itisthesoulofthephysiology.Excitability(兴奋性):Itistheabilityofcertainkindsofcells(excitablecell)tomakeresponsetothestimulus.Essentially,Itistheabilityofcellstogenerateactionpotential.Excitabilityisafundamentalpropertytoalltissuesandcells.Excitation(兴奋):Itsignifiesabeginningofanactivityorincreaseinphy
23、siologicalactivityafterstimulus,suchastheaccelerationoftheheartbeatafterstimulatingthesympatheticnerve.Inhibition(抑制):Inhibitionisastopofanactivityoradecreaseinphysiologicalactivityafterstimulus,suchastheslowingoftheheartbeatafterstimulatingthevagusnerve.Stimulus(刺激):Anychangesfromexternalorinternal
24、environmentalfactorsthatcausesaresponseinasenseorganoranorganismarecalledthestimulus.Itincludesthephysical,chemicalandbiologicalstimuli.Neuralregulation(神经调节):Thefunctionsoforgansororgansystemsareregulatedbythecentralnervoussystemviathereflexes.Thereflexistheregularresponseofeffectorstothestimulusba
25、sedonthereflexarc.Neuro-humoralregulation(神经体液调节):Inmanycases,theendocrinesystemissocloselyrelatedtothenervoussystemthatitcanberegardedasanextensionoftheefferentlimbofthereflexarc.Inthisinstanceitiscalledneuro-humoralregulation.Reflexarc(反射弧):Reflexarcisthepathwayinareflex,itisthebasicunitofintegrat
26、edneuralactivity,consistingofreceptor,afferentnerve,nervouscenter,efferentnerveandeffector.Unconditionedreflex(非条件反射):Afixedreflexwhosemechanismmaybesupposedtobeinheritedasitsfunctioningdoesnotdependonpreviousexperience.Conditionedreflex(条件反射):Alearnedreflexinwhichthenervoussystemistrainedtoproduceanewandunusualresponsetoastimulus.Humoralregulation(体液调节):Thefunctionsoforgansororgansystemsareregulatedbythespecialchemicalsrelea
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