CGP60474 - VEGFR 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECGP60474Cat. No.: HY-11009CAS No.: 164658-13-3分式: CHClNO分量: 355.82作靶点: VEGFR; PKC作通路: Protein Tyrosine Kinase/RTK; Epigenetics; TGF-beta/Smad储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO :

2、50 mg/mL (140.52 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.03 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.03 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 CGP60474种有效的 VEGFR-2 抑制剂，IC50 值为 84 nM，同

3、时为 ATP-竞争性的 PKC 抑制剂。IC50 & Target VEGFR-2 PKC84 nM (IC50)体外研究 CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM 1. CGP60474 is also aPKC inhibitor, with competitive kinetics relative to ATP 2.户使本产品发表的科研献 Sci Rep. 2018 Oct 8;8(1):14969. Oncotarget. 2017 Nov 22;8(65):109135-10

4、9150. Harvard Medical School LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kuo GH, et al. Synthesis and identification of 1,3,5triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinaseinhibitors. J Med Chem. 2005 Jul 14;48(14):4535-46.2.

5、Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-couplingstrategy. J Org Chem. 2005 Jun 24;70(13):5215-20.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895