Flavin-Adenine-Dinucleotide-Disodium-FAD-Na2-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFlavin Adenine Dinucleotide DisodiumCat. No.: HY-B1654ACAS No.: 84366-81-4Synonyms: FAD-Na2; FAD sodium salt分式: CHNNaOP分量: 829.51作靶点: Others作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (prot

2、ect fromlight)溶解性数据体外实验 H2O : 125 mg/mL (150.69 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.2055 mL 6.0277 mL 12.0553 mL5 mM 0.2411 mL 1.2055 mL 2.4111 mL10 mM 0.1206 mL 0.6028 mL 1.2055 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Flavin Adenine

3、Dinucleotide Disodium种氧化还原辅因，蛋质的辅 ，在代谢过程中参与了个重要的酶反应。体外研究Poly(Flavin Adenine Dinucleotide, FAD) characterized by an additional polymer-type redox reaction is ahighly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADHtransducers (0.00 V, pH 7.4), poly(FA

4、D) is characterized by the electrochemical rate constant of 1.8 0.610-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEcharacterized by the dramatically improved stability and, is the most advantageous

5、 NADH transducers foranalytical chemistry 2.体内研究 With flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricularfibrillation threshold (VFT) is significantly cancelled. Flavin Adenine Dinucleotide cancels the effect of CPZ oncanine heart mitochondria. After injec

6、tion of Flavin Adenine Dinucleotide, the dogs show a transienthypotension within 10 min, then their blood pressures recover to the initial level. Flavin Adenine Dinucleotidealso prevents mitochondrial dysfunction induced by chlorpromazine 1.REFERENCES1. Sugiyama S, et al. Protection of chlorpromazin

7、e-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979Sep;20(5):657-65.2. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr1;76(7):2004-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use