Ketoconazole-R-41400-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEKetoconazoleCat. No.: HY-B0105CAS No.: 65277-42-1Synonyms: R-41400; ()-Ketoconazol分式: CHClNO分量: 531.43作靶点: Fungal; Cytochrome P450作通路: Anti-infection; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、months-20C 1 month溶解性数据体外实验 DMSO : 53 mg/mL (99.73 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8817 mL 9.4086 mL 18.8172 mL5 mM 0.3763 mL 1.8817 mL 3.7634 mL10 mM 0.1882 mL 0.9409 mL 1.8817 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ketoconazole

3、 (R-41400)是咪唑类抗真菌剂，是经典的CYP3A4抑制剂,也是CYP24A1的抑制剂。IC50 & Target CYP3A4, CYP24A1.体外研究Ketoconazole (R-41400), an imidazole anti-fungal agent, has often produced features of androgen deficiencyincluding decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in1/2 Maste

4、r of Small Molecules 您边的抑制剂师www.MedChemEmen being treated for chronic mycotic infections 1. Ketoconazole (R-41400) also is a cytochrome P450inhibitor 2. Ketoconazole (R-41400), on the antischistosomal potential of these quinolines againstSchistosoma mansoni infection by evaluating parasitological, h

5、istopathological, and biochemical parameters.Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally withPZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), andKTZ (as group V)+HF (as group VI) (

6、VII). KTZ plus QN or HF produced more inhibition (P 3. CYP24A1inhibitor enhances antiproliferative effects, increases systemic calcitriol exposure, and promotes theactivation of caspase-independent apoptosis pathway 4.户使本产品发表的科研献 Environ Int. 2019 Jun;127:694-703.See more customer validations on HYP

7、ERLINK / www.MedChemEREFERENCES1. Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine againstSchistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75.2. Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70.3. Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151(9):4301-12.McePdfHeightCaution: Product has not been fully validated for medical applications.For re