Methyl-vanillate - Wnt Activator - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMethyl vanillateCat. No.: HY-75342CAS No.: 3943-74-6分式: CHO分量: 182.17作靶点: Wnt; Reactive Oxygen Species作通路: Stem Cell/Wnt; Immunology/Inflammation; MetabolicEnzyme/Protease; NF-B储存式: 4C, stored under nitrogen* In solvent : -80C,

2、6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实验 DMSO : 100 mg/mL (548.94 mM)H2O : 1.67 mg/mL (9.17 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 5.4894 mL 27.4469 mL 54.8938 mL5 mM 1.0979 mL 5.4894 mL 10.9788 mL10 mM 0.5489 mL

3、2.7447 mL 5.4894 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (13.72 mM); Clear solution2. 请依序

4、添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (13.72 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (13.72 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Methyl vanillate枳椇属植物中的提取物， Wnt/-catenin信号通路活化剂 1。苯甲酸酯

5、， 草酸的甲酯。它具有抗氧化作。植物代谢物。IC50 & Target Wnt/-catenin 1体外研究 Methyl vanillate (0-100 M) increases the expression and nuclear translocation of -catenin in calvarialosteoblasts. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts 1.REFERENCES1. Cha PH, et al. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/-catenin pathway and increase bone massin growing or ovariectomized mice. PLoS One. 2014 Jan 22;9(1):e85546.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3