AMG-176 - MCL-1 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAMG-176Cat. No.: HY-101565CAS No.: 1883727-34-1分式: CHClNOS分量: 613.21作靶点: Bcl-2 Family作通路: Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (101.92 mM; Need ultrasonic)Mas

2、s Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.6308 mL 8.1538 mL 16.3076 mL5 mM 0.3262 mL 1.6308 mL 3.2615 mL10 mM 0.1631 mL 0.8154 mL 1.6308 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分

3、 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.39 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (3.39 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 AMG-176种有效的、有服活性的、髓细胞因

4、 1 (MCL-1) 的选择性抑制剂，其 Ki 值为 0.13 nM。IC50 & Target Mcl-10.13 nM (Ki)体外研究 AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), withpotential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits theactivity of MCL

5、-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes andinduces apoptosis in tumor cells 1 2.REFERENCES1. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination withEstablished Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387.2. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3