NBD-556 - HIV 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENBD-556Cat. No.: HY-76648CAS No.: 333353-44-9分式: CHClNO分量: 337.84作靶点: HIV作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 33.33 mg/mL (98.66 mM; Need ultrasonic)H2O : 90%

2、corn oilSolubility: 2.5 mg/mL (7.40 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 NBD-556CD4的分模拟物，能识别HIV-1包膜蛋gp120。REFERENCES1. Narumi, Tetsuo et al. CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorgan

3、ic &Medicinal Chemistry Letters (2010), 20(19), 5853-5858.2. Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep12;45(36):10973-10980.3. Singh IP, Chauthe SK. Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibi

4、tors: 2004-2010. Expert Opin Ther Pat.2011 Mar;21(3):399-416.4. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: