Zoledronic-acid-monohydrate-Zoledronate-monohydrate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEZoledronic acid monohydrateCat. No.: HY-13777ACAS No.: 165800-06-6Synonyms: Zoledronate monohydrate; CGP 42446 monohydrate;CGP42446A monohydrate; ZOL 446 monohydrate分式: CHNOP分量: 290.1作靶点: Autophagy作通路: Autophagy储存式: Powder -20C

2、3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 14.29 mg/mL (49.26 mM; ultrasonic and adjust pH to 8 with NaOH)H2O : 1 mg/mL (3.45 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.4471 mL 17.2354 mL 34.4709 mL5 mM 0.6894 mL 3.4471 mL 6.8942 mL10 mM 0.3447

3、 mL 1.7235 mL 3.4471 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Zoledronic acid monohydrate第三代含氮磷酸盐，能够抑制破细胞介导的吸收，同时具有抗肿瘤的活性。体外研究Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 M, and causes cell death at1/2 Master of Small Molecules 您边的抑制剂师www.Me

4、dChemE1-5 M 1. Zoledronic Acid (50, 100 M) causes dose- and time-dependent apoptosis in CNE-2Z cells aftertreatment for 24, 48, and 72 h. Zoledronic Acid (50 M) also increases the level of ROS, which is supposedto mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chlori

5、de currents inducedby Zoledronic Acid can be blocked by knocking down ClC-3 protein expression 2.REFERENCES1. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr1;3:6.2. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channelactivation. Clin Exp Pharmacol Physiol. 2018 Jun 8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37