N-Acetylprocainamide-Acecainide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN-AcetylprocainamideCat. No.: HY-B1109CAS No.: 32795-44-1Synonyms: Acecainide; NAPA分式: CHNO分量: 277.36作靶点: Potassium Channel作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mon

2、th溶解性数据体外实验 DMSO : 150 mg/mL (540.81 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.6054 mL 18.0271 mL 36.0542 mL5 mM 0.7211 mL 3.6054 mL 7.2108 mL10 mM 0.3605 mL 1.8027 mL 3.6054 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 N-

3、Acetylprocainamide第三代抗律失常剂，能够抑制 K+ 通道。IC50 & Target K+ channel 1体外研究N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEmethacholine. The pIC50 values for N-acetylprocainamide against the contractions ind

4、uced by 0.3 and 1 Mmethacholine are 2.80 0.03 and 2.65 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers 1. N-Acetylprocainamide shows no effect on Na+absorption or Cl- secretion 2.REFERENCES1. Nakahara T, et al. Role of K+ channels in N-acety

5、lprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol.2001 Mar 9;415(1):73-8.2. Plass H, et al. Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium. NaunynSchmiedebergs Arch Pharmacol. 2005 Jun;371(6):492-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-