Dibutyl-phthalate - Other - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDibutyl phthalateCat. No.: HY-Y0304CAS No.: 84-74-2分式: CHO分量: 278.34作靶点: Others作通路: Others储存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 Ethanol : 50 mg/mL (179.64 mM)* means soluble, but satu

2、ration unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.5927 mL 17.9636 mL 35.9273 mL5 mM 0.7185 mL 3.5927 mL 7.1855 mL10 mM 0.3593 mL 1.7964 mL 3.5927 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据

3、储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.98 mM); Clear solution2. 请依序添加每种溶剂： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.98 mM); Clear solution3. 请依序添加每种溶剂： 10% EtOH 90% corn oil1/2 Master of Small Molecules

4、 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (8.98 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Dibutyl phthalate种常的增塑剂，常见于些品包装材料，个护理产品和服药物涂层 1。 可能引起毒性和不良神经为影响 2 3。体外研究 Dibutyl phthalate (0.001 g/mL-1000 g/mL) is detrimental to follicle growth and viability and results insignificant dysregulation of cell

5、cycle and apoptosis gene expression in a dose-specific manner. But MBPdoes not play a role in Dibutyl phthalate toxicity in follicles exposed in vitro 1.体内研究 Dibutyl phthalate (200, 400, or 600 mg/kg/day) induces decrease mice weight, impairment ofspermatogenesis, reduces serum follicle stimulating

6、hormone and testosterone level, alters testicular LDH,increases LPO, and decreases the levels of enzymatic antioxidants with histopathological anomalies 2.Dibutyl phthalate (6.25, 12.5, 25, 50, 100 and 200 mg/kg) could cause some neurobehavioral adverse effectsin mice 3.REFERENCES1. Rasmussen LM, et

7、 al. Effects of in vitro exposure to dibutyl phthalate, mono-butyl phthalate, and acetyl tributyl citrate on ovarian antralfollicle growth and viability. Biol Reprod. 2017 May 1;96(5):1105-1117.2. Aly HA, et al. Dibutyl phthalate induces oxidative stress and impairs spermatogenesis in adult rats. Toxicol Ind Health. 2016Aug;32(8):1467-1477.3. Farzanehfar V, et al. Determination of dibutyl phthalate neurobehavioral toxicity in mice. Food Chem Toxicol. 2016 Aug;94:221-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For r