Costunolide-plus-Costunolide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECostunolideCat. No.: HY-N0036CAS No.: 553-21-9Synonyms: (+)-Costunolide; Costus lactone分式: CHO分量: 232.32作靶点: Apoptosis作通路: Apoptosis储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 49 mg/mL

2、(210.92 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.3044 mL 21.5220 mL 43.0441 mL5 mM 0.8609 mL 4.3044 mL 8.6088 mL10 mM 0.4304 mL 2.1522 mL 4.3044 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验

3、结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.58 mg/mL (11.11 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.58 mg/mL (11.11 mM); Clear solution1/2 Master of Small Mole

4、cules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.58 mg/mL (11.11 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Costunolide有抗炎和抗氧化活性，能介导凋亡。户使本产品发表的科研献 Cell Mol Biol Lett. 2019 Aug 14;24:52. Gene. 2018 Dec 15;678:261-269.See more customer validations on HYPERLINK / www.MedChemEREF

5、ERENCES1. Cheon YH, Song MJ, Kim JY, Costunolide Inhibits Osteoclast Differentiation by Suppressing c-Fos Transcriptional Activity. PhytotherRes. 2013 Jul 6.2. Rasul A, Bao R, Malhi M, Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation andmitochondrial d

6、ysfunction. Molecules. 2013 Jan 24;18(2):1418-33.3. Kretschmer N, Rinner B, Stuendl N, Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporterexpression in human soft tissue sarcoma cells. Planta Med. 2012 Nov;78(16):1749-56.4. Matsuda H, Shimoda H, Ninomiya K,

7、Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, onblood-ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcohol. 2002Mar-Apr;37(2):121-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use