GLP-1-7-36-Acetate-Human-GLP-1-7-36-amide-Acetate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGLP-1(7-36) AcetateCat. No.: HY-P0054CAS No.: 1119517-19-9Synonyms: Human GLP-1-(7-36)-amide Acetate分式: CHNO.xCHOSequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-V

2、al-Lys-Gly-Arg-NH2Sequence Shortening: HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRNH2作靶点: Glucagon Receptor作通路: GPCR/G Protein储存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 16.6 mg/mL (Need ultrasonic and warming)请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIV

3、ITY物活性 GLP-1(7-36) Acetate种主要的肠道激素，在葡萄糖的刺激下，它能促使胰岛 细胞分泌胰岛素。体外研究 Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36)concentrations in the media than those in the control. The glucose treatment also increases active GLP-1secretion from cells in dose-d

4、ependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependentlystimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturatedfatty acids such as oleic, linoleic and linolenic acids than with palmitic acid. The treatment of NCI-H716 cellsw

5、ith CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase isobserved in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE 1.体内研究Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min,1/2 Mas

6、ter of Small Molecules 您边的抑制剂师www.MedChemEfollowed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1levels after 10 min, and followed by a decrease to basal levels at 60 min. Individually, glucose and TOincrease the secretion of GLP-1 in a dose-dependent ma

7、nner. Furthermore, the co-administration of glucoseand TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels inthe portal blood at 10 and 30 min than those in the control mice. When glucose is administered with CPE,active GLP-1 and insulin levels in the port

8、al blood are slightly higher in CPE-administered mice than in thecontrol mice. High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance 1.REFERENCES1. Fujii Y et al. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1(GLP-1(7-36) amide inC57BL/6J mice. J Nutr Sci. 2015 Mar 3McePdfHeightCaution: Product has not been fully validated for medical applicati