Cilnidipine-FRC-8653-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECilnidipineCat. No.: HY-17404CAS No.: 132203-70-4Synonyms: FRC-8653分式: CHNO分量: 492.52作靶点: Calcium Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1

2、month (protect fromlight)溶解性数据体外实验 DMSO : 100 mg/mL (203.04 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.08 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.08 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物

3、活性 Cilnidipine(FRC8653)L型和N型钙离阻断剂，有降压，神经保护活性。REFERENCES1. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism andrenal function in patients with hypertension and type II diabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46

4、-53. doi: 102. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. JHypertens. 2007 Oct;25(10):2178-83.3. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnid

5、ipine in the rat focalbrain ischemia model. Biol Pharm Bull. 2004 Sep;27(9):1388-91.4. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons bycilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5