Pranoprofen - PGE synthase 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPranoprofenCat. No.: HY-B0336CAS No.: 52549-17-4分式: CHNO分量: 255.27作靶点: PGE synthase作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (391.74 mM)* means s

2、oluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.9174 mL 19.5871 mL 39.1742 mL5 mM 0.7835 mL 3.9174 mL 7.8348 mL10 mM 0.3917 mL 1.9587 mL 3.9174 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现

3、配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.79 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.79 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of

4、 Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (9.79 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Pranoprofen甾体抗炎化合物，可作于眼科疾病。REFERENCES1. Akyol-Salman, I., D. Lece-Sertoz, and O. Baykal, Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent asdiclofenac sodium 0.1% a

5、fter strabismus surgery. J Ocul Pharmacol Ther, 2007. 23(3): p. 280-3.2. Notivol, R., M. Martinez, and M.V. Bergamini, Treatment of chronic nonbacterial conjunctivitis with a cyclo-oxygenase inhibitor or acorticosteroid. Pranoprofen Study Group. Am J Ophthalmol, 1994. 117(5): p. 651-6.3. Hosoi, T., et al., Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int, 2009. 54(1): p.1-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37