CX546 - iGluR Agonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECX546Cat. No.: HY-12505CAS No.: 215923-54-9分式: CHNO分量: 247.29作靶点: iGluR; Autophagy作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、 H2O : 2 mg/mL (8.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0438 mL 20.2192 mL 40.4384 mL5 mM 0.8088 mL 4.0438 mL 8.0877 mL10 mM - - -请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 CX546是AMPAR受体选择性激动剂。户使本产品发表的科研献 Exp Neurol. 2018 Jun;304:41-57.1/

3、2 Master of Small Molecules 您边的抑制剂师www.MedChemESee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. JNeurosci. 2000 Jan 1;20(1):8-21.2. Nagarajan N, et

4、al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001Nov;41(6):650-63.3. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther.2002 Dec;303(3):1075-85.4. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice.Neuropsychopharmacology. 2007 Apr;32(4):745-56.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559