Aurora-A-inhibitor-I _Aurora Kinase 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAurora A inhibitor ICat. No.: HY-70061CAS No.: 1158838-45-9分式: CHClFNO分量: 588.08作靶点: Aurora Kinase作通路: Cell Cycle/DNA Damage; Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100

2、mg/mL (170.04 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.25 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.25 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Aurora A inhibitor I有效，度选择的 Aurora A 抑制剂，IC

3、50值为3.4 nM。IC50 & Target Aurora A Aurora B3.4 nM (IC50) 3.4 M (IC50)体外研究 Aurora A inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A inhibitor I is an useful toolcompounds for investigating the cellular role of Aurora A kinases without the complication of also inhibitingAurora B 1.

4、户使本产品发表的科研献 J Biomol Screen. 2013 Oct;18(9):1062-71. Harvard Medical School LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J,Moffat J, Phill

5、ips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG.A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58