F1063-0967 _Phosphatase 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEF1063-0967Cat. No.: HY-101510CAS No.: 613225-56-2分式: CHNOS分量: 484.59作靶点: Phosphatase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (257.95 mM; Need

2、ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0636 mL 10.3180 mL 20.6360 mL5 mM 0.4127 mL 2.0636 mL 4.1272 mL10 mM 0.2064 mL 1.0318 mL 2.0636 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 F1063-0967种双特异性磷酸酶 26 (DUSP26) 抑制剂，其 IC50 值为 11.62 M。IC50 &

3、 Target IC50: 11.62 M (DUSP26) 1体外研究F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 M. Atconcentration above 0.1 M, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 inducesapoptosis in IMR-32 cell line with an IC50 value of 4.13 M. F1063-0967 ha

4、s no effect on HL7702 cell line,1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEand little inhibition effect on SH-SY5Y cell line 1.PROTOCOLCell Assay 1 The IMR-32 cells are plated in 96-well plates with 1103 cells per well. After the cells are allowed to settle for24 h, F1063-0967 (0, 10, 1, and 0

5、.1 M) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 M) is added, then MTT assays are carried outafter 72 h 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. R

6、en JX, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based onpharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820