Desvenlafaxine-O-Desmethylvenlafaxine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDesvenlafaxineCat. No.: HY-B0602CAS No.: 93413-62-8Synonyms: O-Desmethylvenlafaxine分式: CHNO分量: 263.38作靶点: Serotonin Transporter作通路: Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实

2、验 DMSO : 50 mg/mL (189.84 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.7968 mL 18.9840 mL 37.9680 mL5 mM 0.7594 mL 3.7968 mL 7.5936 mL10 mM 0.3797 mL 1.8984 mL 3.7968 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠

3、性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.49 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.49 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn o

4、il1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (9.49 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Desvenlafaxine5-羟胺（5-HT）和去甲肾上腺素（NE）重 吸收抑制剂，Ki为40.2 nM和558.4 nM。REFERENCES1. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.

5、 J Pharmacol Exp Ther, 2006.318(2): p. 657-65.2. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another me too drug? Ann Pharmacother, 2008. 42(10): p. 1439-46.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955